Overcoming immune evasion with innovative multi-target approaches for glioblastoma
Glioblastoma (GBM) cells leverage complex endogenous and environmental regulatory mechanisms to drive proliferation, invasion, and metastasis. Tumor immune evasion, facilitated by a multifactorial network, poses a significant challenge to effective therapy, as evidenced by the limited clinical benef...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541467/full |
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| author | Hai Su Yin Peng Yilong Wu Xiaoli Zeng Xiaoli Zeng Xiaoli Zeng |
| author_facet | Hai Su Yin Peng Yilong Wu Xiaoli Zeng Xiaoli Zeng Xiaoli Zeng |
| author_sort | Hai Su |
| collection | DOAJ |
| description | Glioblastoma (GBM) cells leverage complex endogenous and environmental regulatory mechanisms to drive proliferation, invasion, and metastasis. Tumor immune evasion, facilitated by a multifactorial network, poses a significant challenge to effective therapy, as evidenced by the limited clinical benefits of monotherapies, highlighting the adaptive nature of immune evasion. This review explores glioblastoma’s immune evasion mechanisms, the role of ICIs in the tumor microenvironment, and recent clinical advancements, offering theoretical insights and directions for monotherapy and combination therapy in glioblastoma management. |
| format | Article |
| id | doaj-art-586f380c198445d6be4a19e93f38d99a |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-586f380c198445d6be4a19e93f38d99a2025-01-22T07:13:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15414671541467Overcoming immune evasion with innovative multi-target approaches for glioblastomaHai Su0Yin Peng1Yilong Wu2Xiaoli Zeng3Xiaoli Zeng4Xiaoli Zeng5Department of Neurosurgery, Yongchuan Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurosurgery, Yongchuan Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurosurgery, Yongchuan Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaJiangxi “Flagship” Oncology Department of Synergy for Chinese and Western Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Oncology, Jiangxi Clinical Research Center for Cancer, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaGlioblastoma (GBM) cells leverage complex endogenous and environmental regulatory mechanisms to drive proliferation, invasion, and metastasis. Tumor immune evasion, facilitated by a multifactorial network, poses a significant challenge to effective therapy, as evidenced by the limited clinical benefits of monotherapies, highlighting the adaptive nature of immune evasion. This review explores glioblastoma’s immune evasion mechanisms, the role of ICIs in the tumor microenvironment, and recent clinical advancements, offering theoretical insights and directions for monotherapy and combination therapy in glioblastoma management.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541467/fullglioblastomaimmune evasionimmunotherapyPD-1immune checkpoint |
| spellingShingle | Hai Su Yin Peng Yilong Wu Xiaoli Zeng Xiaoli Zeng Xiaoli Zeng Overcoming immune evasion with innovative multi-target approaches for glioblastoma Frontiers in Immunology glioblastoma immune evasion immunotherapy PD-1 immune checkpoint |
| title | Overcoming immune evasion with innovative multi-target approaches for glioblastoma |
| title_full | Overcoming immune evasion with innovative multi-target approaches for glioblastoma |
| title_fullStr | Overcoming immune evasion with innovative multi-target approaches for glioblastoma |
| title_full_unstemmed | Overcoming immune evasion with innovative multi-target approaches for glioblastoma |
| title_short | Overcoming immune evasion with innovative multi-target approaches for glioblastoma |
| title_sort | overcoming immune evasion with innovative multi target approaches for glioblastoma |
| topic | glioblastoma immune evasion immunotherapy PD-1 immune checkpoint |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541467/full |
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