The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

IntroductionDeglycosylated azithromycin (Deg-AZM), a new transgelin agonist with positive therapeutic effects on slow transit constipation, has been approved for clinical trials in 2024. This work investigated the drug metabolism and transport of Deg-AZM to provide research data for further developm...

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Main Authors: Xiaoting Gu, Xiaohe Li, Weixue Tian, Chaoyue Zheng, Yutian Cai, Xiang Xu, Conglu Zhao, Hongting Liu, Yao Sun, Zhilin Luo, Shuwen Zhu, Honggang Zhou, Xiaoyu Ai, Cheng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1510903/full
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