Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways

Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways

AimsCathepsins are essential lysosomal enzymes that maintain organismal homeostasis by degrading extracellular substrates. The inflammatory cytokine interleukin-6 (IL-6) increases the production of cathepsins through the caveolin-1 (Cav-1) and c-Jun N-terminal kinase (JNK) signaling pathways, which...

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Bibliographic Details
Main Authors: Ayaka Goto, Kazuhiro Omori, Tomoko Yamaguchi-Tomikawa, Hiroya Kobayashi, Yuki Shinoda-Ito, Kimito Hirai, Atsushi Ikeda, Shogo Takashiba
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Dental Medicine
Subjects:
cathepsin B
cathepsin L
human gingival fibroblast
interleukin-6
caveolin
Online Access:https://www.frontiersin.org/articles/10.3389/fdmed.2025.1547222/full
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https://www.frontiersin.org/articles/10.3389/fdmed.2025.1547222/full

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