Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice

Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice

Abstract Iron overload has been associated with cerebrovascular disease and cognitive impairment in β-thalassaemia patients, typically appearing earlier than in the general population. However, the mechanisms of iron overload on cerebrovascular pathology remain unclear. This study investigated the e...

Full description

Saved in:
Bibliographic Details
Main Authors: Parinda Jamrus, Nuttanan Pholngam, Benjaporn Kiatpakdee, Kittikun Viwatpinyo, Jim Vadolas, Sukonthar Ngampramuan, Saovaros Svasti, Pornthip Chaichompoo
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Blood-brain barrier
Cognitive impairment
Brain pathology
Iron overload
β-Thalassaemia
Online Access:https://doi.org/10.1038/s41598-024-84395-z
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-024-84395-z

Similar Items