Celastrol improves endothelial function in diet-induced obesity mice via attenuating endoplasmic reticulum stress through the activation of AMPK pathway

Celastrol improves endothelial function in diet-induced obesity mice via attenuating endoplasmic reticulum stress through the activation of AMPK pathway

Abstract Background Diet-induced obesity (DIO) is a significant factor in endothelial dysfunction. Celastrol, a potent anti-inflammatory and anti-oxidative pentacyclic triterpene, has shown promise as a protective agent against cardiovascular disease. However, the specific protective effects and mec...

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Bibliographic Details
Main Authors: Cheng Yu, Weihong Lin, Jing Yang, Qiong Jiang, Wenkun Liu, Hongjin Liu, Yong Lin, Litao Wang, Lei Chen, Yu Huang, Lianglong Chen
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
Celastrol
Endoplasmic reticulum stress
Obesity
Endothelial function
AMPK
Online Access:https://doi.org/10.1186/s10020-025-01259-6
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https://doi.org/10.1186/s10020-025-01259-6

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