A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

Abstract The Type VI secretion system (T6SS) is a key virulence mechanism utilized by many Gram‐negative bacteria to mediate the microbial competition and host pathogenesis. Despite the identification of diverse T6SS effectors targeting eukaryotic or prokaryotic cells, the trans‐kingdom T6SS effecto...

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Main Authors: Li Song, Lei Xu, Pengfei Zhang, Shuying Li, Yichen Qu, Yixin Zhao, Zhenkun Shi, Ruiqi Ma, Yongdong Li, Yi Chen, Yao Wang, Zhengfan Jiang, Gehong Wei, Xihui Shen
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
apoptosis
DNA damage
DNase
trans‐kingdom effector
Type VI secretion systems (T6SSs)
Yersinia pseudotuberculosis
Online Access:https://doi.org/10.1002/advs.202504086
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https://doi.org/10.1002/advs.202504086

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