Neutrophils restricted contribution of CCRL2 genetic variants to COVID-19 severity

Neutrophils restricted contribution of CCRL2 genetic variants to COVID-19 severity

The 3p21.31 locus is the most robust genomic region associated with COVID-19 severity. This locus contains a main chemokine receptor (CKR) cluster. We tested expression quantitative trait loci (eQTL) targeting the 3p21.31 CKR cluster linked to COVID-19 hospitalization in Europeans from the COVID-19...

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Bibliographic Details
Main Authors: Mattia Laffranchi, Elvezia Maria Paraboschi, Francisco Bianchetto-Aguilera, Nicola Tamassia, Sara Gasperini, Elisa Gardiman, Arianna Piserà, Annalisa Del Prete, Pietro Invernizzi, Angela Gismondi, Alberto Mantovani, Marco A. Cassatella, Rosanna Asselta, Silvano Sozzani
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
GWAS
COVID-19
ChIP-seq
Neutrophils
SNP
eQTL
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024172982
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