Selective Modulation of Osteoclast Function by <i>Bothrops moojeni</i> Venom and Its Fractions: Implications for Therapeutic Targeting in Bone Diseases

Selective Modulation of Osteoclast Function by <i>Bothrops moojeni</i> Venom and Its Fractions: Implications for Therapeutic Targeting in Bone Diseases

Our study explores the differential effects of <i>Bothrops moojeni</i> venom and its fractions on osteoclast (OC) morphology, function, and osteoclastogenesis. The crude venom and its high-molecular-weight (HMW) fraction disrupt critical OC processes, including F-actin ring formation and...

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Bibliographic Details
Main Authors: Fernanda D’Amélio, Hugo Vigerelli, Isabel de Fátima Correia Batista, Rodrigo Pinheiro Araldi, Álvaro R. B. Prieto-da-Silva, Daniel Carvalho Pimenta, Irina Kerkis
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Toxins
Subjects:
<i>Bothrops moojeni</i>
high- and low-molecular-weight fraction
osteoclast
morphology
function
secretome
Online Access:https://www.mdpi.com/2072-6651/17/3/141
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