Unravelling the conundrum of nucleolar NR2F1 localization using antibody-based approaches in vitro and in vivo

Unravelling the conundrum of nucleolar NR2F1 localization using antibody-based approaches in vitro and in vivo

Abstract As a transcription factor, NR2F1 regulates spatiotemporal gene expression in the nucleus particularly during development. Aberrant NR2F1 causes the rare neurodevelopmental disorder Bosch-Boonstra-Schaaf Optic Atrophy Syndrome. In addition, altered NR2F1 expression is frequently observed in...

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Main Authors: Michele Bertacchi, Susanne Theiß, Ayat Ahmed, Michael Eibl, Agnès Loubat, Gwendoline Maharaux, Wanchana Phromkrasae, Krittalak Chakrabandhu, Aylin Camgöz, Marco Antonaci, Christian Patrick Schaaf, Michèle Studer, Magdalena Laugsch
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07985-1
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https://doi.org/10.1038/s42003-025-07985-1

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