Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy
Primary biliary cirrhosis (PBC) is characterized by antimitochondrial autoantibodies (AMAs) in patients' sera and histologically by chronic nonsuppurative destructive cholangitis in small bile ducts, eventually followed by extensive bile duct loss and biliary cirrhosis. The autoimmune-mediated...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/452143 |
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| author | Motoko Sasaki Yasuni Nakanuma |
| author_facet | Motoko Sasaki Yasuni Nakanuma |
| author_sort | Motoko Sasaki |
| collection | DOAJ |
| description | Primary biliary cirrhosis (PBC) is characterized by antimitochondrial autoantibodies (AMAs) in patients' sera and histologically by chronic nonsuppurative destructive cholangitis in small bile ducts, eventually followed by extensive bile duct loss and biliary cirrhosis. The autoimmune-mediated pathogenesis of bile duct lesions, including the significance of AMAs, triggers of the autoimmune process, and so on remain unclear. We have reported that cellular senescence in biliary epithelial cells (BECs) may be involved in bile duct lesions and that autophagy may precede the process of biliary epithelial senescence in PBC. Interestingly, BECs in damaged bile ducts show characteristicsof cellular senescence and autophagy in PBC. A suspected causative factor of biliary epithelial senescence is oxidative stress. Furthermore, senescent BECs may modulate the microenvironment around bile ducts by expressing various chemokines and cytokines called senescence-associated secretory phenotypes and contribute to the pathogenesis in PBC. |
| format | Article |
| id | doaj-art-56f87cb9ee6e4eedb1bafe679d4b3f16 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-56f87cb9ee6e4eedb1bafe679d4b3f162025-02-03T01:07:42ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/452143452143Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and AutophagyMotoko Sasaki0Yasuni Nakanuma1Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, JapanDepartment of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, JapanPrimary biliary cirrhosis (PBC) is characterized by antimitochondrial autoantibodies (AMAs) in patients' sera and histologically by chronic nonsuppurative destructive cholangitis in small bile ducts, eventually followed by extensive bile duct loss and biliary cirrhosis. The autoimmune-mediated pathogenesis of bile duct lesions, including the significance of AMAs, triggers of the autoimmune process, and so on remain unclear. We have reported that cellular senescence in biliary epithelial cells (BECs) may be involved in bile duct lesions and that autophagy may precede the process of biliary epithelial senescence in PBC. Interestingly, BECs in damaged bile ducts show characteristicsof cellular senescence and autophagy in PBC. A suspected causative factor of biliary epithelial senescence is oxidative stress. Furthermore, senescent BECs may modulate the microenvironment around bile ducts by expressing various chemokines and cytokines called senescence-associated secretory phenotypes and contribute to the pathogenesis in PBC.http://dx.doi.org/10.1155/2012/452143 |
| spellingShingle | Motoko Sasaki Yasuni Nakanuma Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy International Journal of Hepatology |
| title | Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy |
| title_full | Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy |
| title_fullStr | Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy |
| title_full_unstemmed | Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy |
| title_short | Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy |
| title_sort | novel approach to bile duct damage in primary biliary cirrhosis participation of cellular senescence and autophagy |
| url | http://dx.doi.org/10.1155/2012/452143 |
| work_keys_str_mv | AT motokosasaki novelapproachtobileductdamageinprimarybiliarycirrhosisparticipationofcellularsenescenceandautophagy AT yasuninakanuma novelapproachtobileductdamageinprimarybiliarycirrhosisparticipationofcellularsenescenceandautophagy |