Prevalence and Associated Factors of Visual Hallucinations in Patients with Vascular Cognitive Impairment
Visual hallucinations (VHs) are striking features for dementia, especially dementia with Lewy bodies (DLB). We aimed to study the frequency and associated factors of VH in vascular cognitive impairment (VCI) and investigate the feasibility of clinically diagnosing the mixed pathology of VCI with DLB...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2021/8866763 |
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| author | Chih-Lin Chen Min-Hsien Hsu Chao-Hsien Hung Pai-Yi Chiu Chung-Hsiang Liu |
| author_facet | Chih-Lin Chen Min-Hsien Hsu Chao-Hsien Hung Pai-Yi Chiu Chung-Hsiang Liu |
| author_sort | Chih-Lin Chen |
| collection | DOAJ |
| description | Visual hallucinations (VHs) are striking features for dementia, especially dementia with Lewy bodies (DLB). We aimed to study the frequency and associated factors of VH in vascular cognitive impairment (VCI) and investigate the feasibility of clinically diagnosing the mixed pathology of VCI with DLB. This is a multicentre registration study. A consecutive series of VCI patients with and without dementia were enrolled. Frequency of VH and associated factors, including age, gender, education, disease severity, DLB clinical features, vascular risk factors, cognitive function, and neuropsychiatric symptoms, were compared between VCI with VH (VH+) and without VH (VH−). Among the 1281 patients analysed, 155 (12.1%) had VH. The VH+ group was older (t=5.07; p<0.001), was more likely to be female (χ2=13.46; p<0.001), and has a higher clinical dementia rating (χ2=70.51; p<0.001). After adjusting for age, gender, and disease severity, the VH+ group had poorer cognition and more severe neuropsychiatric symptoms. The VH+ group was more associated with DLB features in fluctuating cognition (OR=2.48; p<0.001), parkinsonism (OR=1.85; p=0.001), rapid eye movement (REM) behavioral disorder (OR=4.56; p<0.001), and ≧2 DLB core features (OR=26.01; p<0.001). VCI patients with VH tend to have more severe dementia, neuropsychiatric symptoms, and poorer cognitive function. Additionally, highly associated with clinical DLB features in VCI with VH raised the possibility of mixed pathology with DLB in this group. More than two core features in VCI might help in diagnosing a mixed pathology with DLB. |
| format | Article |
| id | doaj-art-56df0de6b5304c429f1fd313c60f91db |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-56df0de6b5304c429f1fd313c60f91db2025-02-03T01:10:54ZengWileyBehavioural Neurology0953-41801875-85842021-01-01202110.1155/2021/88667638866763Prevalence and Associated Factors of Visual Hallucinations in Patients with Vascular Cognitive ImpairmentChih-Lin Chen0Min-Hsien Hsu1Chao-Hsien Hung2Pai-Yi Chiu3Chung-Hsiang Liu4Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua 505, TaiwanDepartment of Neurology, Show Chwan Memorial Hospital, Changhua 500, TaiwanDepartment of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua 505, TaiwanDepartment of Neurology, Show Chwan Memorial Hospital, Changhua 500, TaiwanDepartment of Neurology, China Medical University Hospital, Taichung 404, TaiwanVisual hallucinations (VHs) are striking features for dementia, especially dementia with Lewy bodies (DLB). We aimed to study the frequency and associated factors of VH in vascular cognitive impairment (VCI) and investigate the feasibility of clinically diagnosing the mixed pathology of VCI with DLB. This is a multicentre registration study. A consecutive series of VCI patients with and without dementia were enrolled. Frequency of VH and associated factors, including age, gender, education, disease severity, DLB clinical features, vascular risk factors, cognitive function, and neuropsychiatric symptoms, were compared between VCI with VH (VH+) and without VH (VH−). Among the 1281 patients analysed, 155 (12.1%) had VH. The VH+ group was older (t=5.07; p<0.001), was more likely to be female (χ2=13.46; p<0.001), and has a higher clinical dementia rating (χ2=70.51; p<0.001). After adjusting for age, gender, and disease severity, the VH+ group had poorer cognition and more severe neuropsychiatric symptoms. The VH+ group was more associated with DLB features in fluctuating cognition (OR=2.48; p<0.001), parkinsonism (OR=1.85; p=0.001), rapid eye movement (REM) behavioral disorder (OR=4.56; p<0.001), and ≧2 DLB core features (OR=26.01; p<0.001). VCI patients with VH tend to have more severe dementia, neuropsychiatric symptoms, and poorer cognitive function. Additionally, highly associated with clinical DLB features in VCI with VH raised the possibility of mixed pathology with DLB in this group. More than two core features in VCI might help in diagnosing a mixed pathology with DLB.http://dx.doi.org/10.1155/2021/8866763 |
| spellingShingle | Chih-Lin Chen Min-Hsien Hsu Chao-Hsien Hung Pai-Yi Chiu Chung-Hsiang Liu Prevalence and Associated Factors of Visual Hallucinations in Patients with Vascular Cognitive Impairment Behavioural Neurology |
| title | Prevalence and Associated Factors of Visual Hallucinations in Patients with Vascular Cognitive Impairment |
| title_full | Prevalence and Associated Factors of Visual Hallucinations in Patients with Vascular Cognitive Impairment |
| title_fullStr | Prevalence and Associated Factors of Visual Hallucinations in Patients with Vascular Cognitive Impairment |
| title_full_unstemmed | Prevalence and Associated Factors of Visual Hallucinations in Patients with Vascular Cognitive Impairment |
| title_short | Prevalence and Associated Factors of Visual Hallucinations in Patients with Vascular Cognitive Impairment |
| title_sort | prevalence and associated factors of visual hallucinations in patients with vascular cognitive impairment |
| url | http://dx.doi.org/10.1155/2021/8866763 |
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