Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapy
Abstract Initially, it was believed that glycolysis and DNA damage repair (DDR) were two distinct biological processes that independently regulate tumor progression. The former metabolic reprogramming rapidly generates energy and generous intermediate metabolites, supporting the synthetic metabolism...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Cell Communication and Signaling |
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| Online Access: | https://doi.org/10.1186/s12964-025-02047-9 |
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| author | Fengyao Sun Wen Li Ruihang Du Mingchan Liu Yi Cheng Jianxing Ma Siyuan Yan |
| author_facet | Fengyao Sun Wen Li Ruihang Du Mingchan Liu Yi Cheng Jianxing Ma Siyuan Yan |
| author_sort | Fengyao Sun |
| collection | DOAJ |
| description | Abstract Initially, it was believed that glycolysis and DNA damage repair (DDR) were two distinct biological processes that independently regulate tumor progression. The former metabolic reprogramming rapidly generates energy and generous intermediate metabolites, supporting the synthetic metabolism and proliferation of tumor cells. While the DDR plays a pivotal role in preserving genomic stability, thus resisting cellular senescence and cell death under both physiological and radio-chemotherapy conditions. Recently, an increasing number of studies have shown closely correlation between these two biological processes, and then promoting tumor progression. For instance, lactic acid, the product of glycolysis, maintains an acidic tumor microenvironment that not only fosters cell proliferation and invasion but also facilitates DDR by enhancing AKT activity. Here, we provide a comprehensive overview of the enzymes and metabolites involved in glycolysis, along with the primary methods for DDR. Meanwhile, this review explores existing knowledge of glycolysis enzymes and metabolites in regulating DDR. Moreover, considering the significant roles of glycolysis and DDR in tumor development and radio-chemotherapy resistance, the present review discusses effective direct or indirect therapeutic strategies targeted to glycolysis and DDR. |
| format | Article |
| id | doaj-art-56875c4ac58d490fa688efe475792a07 |
| institution | Kabale University |
| issn | 1478-811X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj-art-56875c4ac58d490fa688efe475792a072025-01-26T12:44:54ZengBMCCell Communication and Signaling1478-811X2025-01-0123111710.1186/s12964-025-02047-9Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapyFengyao Sun0Wen Li1Ruihang Du2Mingchan Liu3Yi Cheng4Jianxing Ma5Siyuan Yan6Precision Medicine Laboratory for Chronic Non-Communicable Diseases of Shandong Province, Institute of Precision Medicine, Jining Medical UniversityPrecision Medicine Laboratory for Chronic Non-Communicable Diseases of Shandong Province, Institute of Precision Medicine, Jining Medical UniversityPrecision Medicine Laboratory for Chronic Non-Communicable Diseases of Shandong Province, Institute of Precision Medicine, Jining Medical UniversityPrecision Medicine Laboratory for Chronic Non-Communicable Diseases of Shandong Province, Institute of Precision Medicine, Jining Medical UniversityPrecision Medicine Laboratory for Chronic Non-Communicable Diseases of Shandong Province, Institute of Precision Medicine, Jining Medical UniversityPrecision Medicine Laboratory for Chronic Non-Communicable Diseases of Shandong Province, Institute of Precision Medicine, Jining Medical UniversityPrecision Medicine Laboratory for Chronic Non-Communicable Diseases of Shandong Province, Institute of Precision Medicine, Jining Medical UniversityAbstract Initially, it was believed that glycolysis and DNA damage repair (DDR) were two distinct biological processes that independently regulate tumor progression. The former metabolic reprogramming rapidly generates energy and generous intermediate metabolites, supporting the synthetic metabolism and proliferation of tumor cells. While the DDR plays a pivotal role in preserving genomic stability, thus resisting cellular senescence and cell death under both physiological and radio-chemotherapy conditions. Recently, an increasing number of studies have shown closely correlation between these two biological processes, and then promoting tumor progression. For instance, lactic acid, the product of glycolysis, maintains an acidic tumor microenvironment that not only fosters cell proliferation and invasion but also facilitates DDR by enhancing AKT activity. Here, we provide a comprehensive overview of the enzymes and metabolites involved in glycolysis, along with the primary methods for DDR. Meanwhile, this review explores existing knowledge of glycolysis enzymes and metabolites in regulating DDR. Moreover, considering the significant roles of glycolysis and DDR in tumor development and radio-chemotherapy resistance, the present review discusses effective direct or indirect therapeutic strategies targeted to glycolysis and DDR.https://doi.org/10.1186/s12964-025-02047-9GlycolysisDNA damage repairGenomic stabilityTumorResistance |
| spellingShingle | Fengyao Sun Wen Li Ruihang Du Mingchan Liu Yi Cheng Jianxing Ma Siyuan Yan Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapy Cell Communication and Signaling Glycolysis DNA damage repair Genomic stability Tumor Resistance |
| title | Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapy |
| title_full | Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapy |
| title_fullStr | Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapy |
| title_full_unstemmed | Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapy |
| title_short | Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapy |
| title_sort | impact of glycolysis enzymes and metabolites in regulating dna damage repair in tumorigenesis and therapy |
| topic | Glycolysis DNA damage repair Genomic stability Tumor Resistance |
| url | https://doi.org/10.1186/s12964-025-02047-9 |
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