Heterogeneous subpopulations in Escherichia coli strains acquire adaptive resistance to imipenem treatment through rapid transcriptional regulation

Heterogeneous subpopulations in Escherichia coli strains acquire adaptive resistance to imipenem treatment through rapid transcriptional regulation

IntroductionHeteroresistance is a well-known phenomenon contributing to treatment failure in bacterial infections. Previous research has traditionally linked it to genetic mechanisms, emphasizing fixed subpopulations with specific resistance mutations. Recent studies appreciated that bacterial subpo...

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Bibliographic Details
Main Authors: YunTao Luo, Rong Xu, Bo Yuan, WeiHua Yang, YunHeng Zhou, Yuan Tian, QingZhong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
heteroresistance
transcriptional regulation
Escherichia coli
non-genetic mechanism
fitness cost
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1563316/full
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