The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications
Abstract Diabetic cardiomyopathy (DbCM), a significant chronic complication of diabetes, manifests as myocardial hypertrophy, fibrosis, and other pathological alterations that substantially impact cardiac function and elevate the risk of cardiovascular diseases and patient mortality. Myocardial ener...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Clinical Epigenetics |
| Online Access: | https://doi.org/10.1186/s13148-025-01814-2 |
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| author | Dongze Li Li Zhang Qiming Gong Huilan Deng Changfang Luo Tingting Zhou Wei Huang Yong Xu |
| author_facet | Dongze Li Li Zhang Qiming Gong Huilan Deng Changfang Luo Tingting Zhou Wei Huang Yong Xu |
| author_sort | Dongze Li |
| collection | DOAJ |
| description | Abstract Diabetic cardiomyopathy (DbCM), a significant chronic complication of diabetes, manifests as myocardial hypertrophy, fibrosis, and other pathological alterations that substantially impact cardiac function and elevate the risk of cardiovascular diseases and patient mortality. Myocardial energy metabolism disturbances in DbCM, encompassing glucose, fatty acid, ketone body and lactate metabolism, are crucial factors that contribute to the progression of DbCM. In recent years, novel protein post-translational modifications (PTMs) such as lactylation, β-hydroxybutyrylation, and succinylation have been demonstrated to be intimately associated with the myocardial energy metabolism process, and in conjunction with acetylation, they participate in the regulation of protein activity and gene expression activity in cardiomyocytes. This review examines the epigenetic pathogenesis of DbCM, primarily focusing on myocardial energy metabolism perturbations and novel PTMs associated with them. It provides a detailed analysis of the mechanisms of these novel PTMs in DbCM to enhance the understanding of DbCM pathophysiology and establish a theoretical foundation for the development of new treatment strategies for DbCM. |
| format | Article |
| id | doaj-art-566a2f88504e4f41ba338c3eba3682a2 |
| institution | Kabale University |
| issn | 1868-7083 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj-art-566a2f88504e4f41ba338c3eba3682a22025-01-26T12:39:11ZengBMCClinical Epigenetics1868-70832025-01-0117111410.1186/s13148-025-01814-2The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modificationsDongze Li0Li Zhang1Qiming Gong2Huilan Deng3Changfang Luo4Tingting Zhou5Wei Huang6Yong Xu7Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical UniversitySichuan Clinical Research Center for Diabetes and Metabolic DiseasesDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical UniversityDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical UniversityDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical UniversityDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical UniversityDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical UniversityDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical UniversityAbstract Diabetic cardiomyopathy (DbCM), a significant chronic complication of diabetes, manifests as myocardial hypertrophy, fibrosis, and other pathological alterations that substantially impact cardiac function and elevate the risk of cardiovascular diseases and patient mortality. Myocardial energy metabolism disturbances in DbCM, encompassing glucose, fatty acid, ketone body and lactate metabolism, are crucial factors that contribute to the progression of DbCM. In recent years, novel protein post-translational modifications (PTMs) such as lactylation, β-hydroxybutyrylation, and succinylation have been demonstrated to be intimately associated with the myocardial energy metabolism process, and in conjunction with acetylation, they participate in the regulation of protein activity and gene expression activity in cardiomyocytes. This review examines the epigenetic pathogenesis of DbCM, primarily focusing on myocardial energy metabolism perturbations and novel PTMs associated with them. It provides a detailed analysis of the mechanisms of these novel PTMs in DbCM to enhance the understanding of DbCM pathophysiology and establish a theoretical foundation for the development of new treatment strategies for DbCM.https://doi.org/10.1186/s13148-025-01814-2 |
| spellingShingle | Dongze Li Li Zhang Qiming Gong Huilan Deng Changfang Luo Tingting Zhou Wei Huang Yong Xu The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications Clinical Epigenetics |
| title | The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications |
| title_full | The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications |
| title_fullStr | The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications |
| title_full_unstemmed | The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications |
| title_short | The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications |
| title_sort | role of myocardial energy metabolism perturbations in diabetic cardiomyopathy from the perspective of novel protein post translational modifications |
| url | https://doi.org/10.1186/s13148-025-01814-2 |
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