Biomimetic self-assembly nanoparticles inhibit serpinB9 and synergistically enhance COD-induced ferroptosis for cancer therapy

Biomimetic self-assembly nanoparticles inhibit serpinB9 and synergistically enhance COD-induced ferroptosis for cancer therapy

Granzyme B (GrB), a crucial serine protease stored in immune cells, plays a pivotal role in combating tumors primarily through GrB-induced apoptosis. However, the elevated expression of SerpinB9 (Sb9), which is a physiological inhibitor of GrB, within tumors acts as an impediment to GrB-induced apop...

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Bibliographic Details
Main Authors: Ruyue Han, Pengcheng Sun, Min Zhou, Wenjie Xu, Xinyan Hao, Yanjin Peng, Yucheng Tang, Xinying Liu, Hai Huang, Mengen Guo, Tiantian Tang, Xiongbin Hu, Daxiong Xiang, Junyong Wu
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Cancer
Delivery system
SerpinB9
Cholesterol oxidase (COD)
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425005526
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