Colorectal cancer in Lynch syndrome families: consequences of gene germline mutations and the gut microbiota

Colorectal cancer in Lynch syndrome families: consequences of gene germline mutations and the gut microbiota

Abstract Background Lynch syndrome (LS)-associated colorectal cancer (CRC) always ascribes to pathogenic germline mutations in mismatch repair (MMR) genes. However, the penetrance of CRC varies among those with the same MMR gene mutation. Thus, we hypothesized that the gut microbiota is also involve...

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Main Authors: Xuexin Wang, Zhijun Zheng, Dongliang Yu, Xiaojue Qiu, Ting Yang, Ruoran Li, Jing Liu, Xin Wang, Peng Jin, Jianqiu Sheng, Nan Qin, Na Li, Junfeng Xu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Lynch syndrome
Colorectal cancer
Gut microbiota
16S rRNA gene amplicon sequencing
Germline gene mutation
Butyrate-producing bacteria
Online Access:https://doi.org/10.1186/s13023-025-03543-4
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https://doi.org/10.1186/s13023-025-03543-4

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