Sodium butyrate in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain, bloating, and altered bowel habits. Although its pathophysiology is not fully understood, factors such as gut microbiota imbalance, increased intestinal permeability, and low-grade inflam...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2025-06-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/60166 |
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| author | Aleksandra Kołodziej Wiktoria Zamirska Nadia Hornig Aleksandra Cieplak Zuzanna Czyżewicz |
| author_facet | Aleksandra Kołodziej Wiktoria Zamirska Nadia Hornig Aleksandra Cieplak Zuzanna Czyżewicz |
| author_sort | Aleksandra Kołodziej |
| collection | DOAJ |
| description | Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain, bloating, and altered bowel habits. Although its pathophysiology is not fully understood, factors such as gut microbiota imbalance, increased intestinal permeability, and low-grade inflammation are considered key contributors. Sodium butyrate, a short-chain fatty acid produced by bacterial fermentation of dietary fiber, plays an important role in gut health. It supports intestinal barrier function, reduces inflammation, and influences microbiota composition. This review summarizes current knowledge on the role of sodium butyrate in IBS, focusing on its mechanisms of action and clinical relevance. A literature review was conducted using databases such as PubMed and Google Scholar with relevant MeSH keywords. Preclinical and clinical studies indicate that sodium butyrate may help alleviate IBS symptoms by enhancing epithelial integrity and modulating inflammation. However, variations in study design and dosing limit clear conclusions. Further randomized trials are needed to confirm its efficacy and define optimal treatment strategies.
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| format | Article |
| id | doaj-art-55ea25332a6e4560a058b51fa46813b2 |
| institution | DOAJ |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-55ea25332a6e4560a058b51fa46813b22025-08-20T02:39:28ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-06-018210.12775/JEHS.2025.82.60166Sodium butyrate in Irritable Bowel SyndromeAleksandra Kołodziej0https://orcid.org/0009-0007-7322-3116Wiktoria Zamirska1https://orcid.org/0009-0006-6520-1876Nadia Hornig2https://orcid.org/0009-0001-3247-4660Aleksandra Cieplak3https://orcid.org/0009-0008-2700-5211Zuzanna Czyżewicz4https://orcid.org/0009-0005-8809-2708Municipal Hospital No. 4 in Gliwice ul. Zygmunta Starego 20, 44-100 Gliwice, PolandKatowice Oncology Centre, ul.Raciborska 26, 40-074 Katowice, Poland Independent Public Health Care Facility of the Ministry of Internal Affairs and Administrationin Katowice named after Sergeant Grzegorz Załoga, ul.WitaStwosza39-41 40-042 Katowice, Poland University Clinical Center named after Prof. K. Gibiński, ul. Medyków 14, 40-514 Katowice, PolandMedical University of Silesia, ul.Poniatowskiego 15, 40-055 Katowice, Poland Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain, bloating, and altered bowel habits. Although its pathophysiology is not fully understood, factors such as gut microbiota imbalance, increased intestinal permeability, and low-grade inflammation are considered key contributors. Sodium butyrate, a short-chain fatty acid produced by bacterial fermentation of dietary fiber, plays an important role in gut health. It supports intestinal barrier function, reduces inflammation, and influences microbiota composition. This review summarizes current knowledge on the role of sodium butyrate in IBS, focusing on its mechanisms of action and clinical relevance. A literature review was conducted using databases such as PubMed and Google Scholar with relevant MeSH keywords. Preclinical and clinical studies indicate that sodium butyrate may help alleviate IBS symptoms by enhancing epithelial integrity and modulating inflammation. However, variations in study design and dosing limit clear conclusions. Further randomized trials are needed to confirm its efficacy and define optimal treatment strategies. https://apcz.umk.pl/JEHS/article/view/60166sodium butyrateirritable bowel syndromeibs |
| spellingShingle | Aleksandra Kołodziej Wiktoria Zamirska Nadia Hornig Aleksandra Cieplak Zuzanna Czyżewicz Sodium butyrate in Irritable Bowel Syndrome Journal of Education, Health and Sport sodium butyrate irritable bowel syndrome ibs |
| title | Sodium butyrate in Irritable Bowel Syndrome |
| title_full | Sodium butyrate in Irritable Bowel Syndrome |
| title_fullStr | Sodium butyrate in Irritable Bowel Syndrome |
| title_full_unstemmed | Sodium butyrate in Irritable Bowel Syndrome |
| title_short | Sodium butyrate in Irritable Bowel Syndrome |
| title_sort | sodium butyrate in irritable bowel syndrome |
| topic | sodium butyrate irritable bowel syndrome ibs |
| url | https://apcz.umk.pl/JEHS/article/view/60166 |
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