Pancreatic cancer cells infiltrate nerves through TGFbeta1-driven perineural epithelial-to-mesenchymal-like transdifferentiation

Pancreatic cancer cells infiltrate nerves through TGFbeta1-driven perineural epithelial-to-mesenchymal-like transdifferentiation

Neural invasion is a prognostic hallmark of pancreatic ductal adenocarcinoma (PDAC), yet the underlying mechanisms behind the disruption of perineural barriers and access of cancer cells into intrapancreatic nerves remain poorly understood. This study aimed to investigate the role of epithelial-mese...

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Bibliographic Details
Main Authors: Theresa Krauss, Ibrahim Halil Gürcinar, Ulrike Bourquain, Maren Hieber, Evelyn N. Krohmer, Nan Wu, Sergey Tokalov, Rüdiger Goess, Carmen Mota Reyes, Dieter Saur, Helmut Friess, Güralp O. Ceyhan, Ihsan Ekin Demir, Okan Safak
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Pancreatic cancer
TGFbeta1
Epithelial-to-mesenchymal-like transdifferentiation
Nerve infiltration
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000053
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