IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells
IQGAPs are a family of scaffolding proteins with multiple domains, named for the IQ motifs and GTPase activating protein (GAP) related domains. Despite their GAP homology, IQGAP proteins act as effectors for GTP-bound GTPases of the Ras superfamily and do not stimulate GTP hydrolysis. IQGAPs are fou...
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| Format: | Article |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/894817 |
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| author | Katie B. Shannon |
| author_facet | Katie B. Shannon |
| author_sort | Katie B. Shannon |
| collection | DOAJ |
| description | IQGAPs are a family of scaffolding proteins with multiple domains, named for the IQ motifs and GTPase activating protein (GAP) related domains. Despite their GAP homology, IQGAP proteins act as effectors for GTP-bound GTPases of the Ras superfamily and do not stimulate GTP hydrolysis. IQGAPs are found in eukaryotic cells from yeast to human, and localize to actin-containing structures such as lamellipodia, membrane ruffles, cell-cell adhesions, phagocytic cups, and the actomyosin ring formed during cytokinesis. Mammalian IQGAPs also act as scaffolds for signaling pathways. IQGAPs perform their myriad functions through association with a large number of proteins including filamentous actin (F-actin), GTPases, calcium-binding proteins, microtubule binding proteins, kinases, and receptors. The focus of this paper is on recent studies describing new binding partners, mechanisms of regulation, and biochemical and physiological functions of IQGAPs in yeast, amoeba, and mammalian cells. |
| format | Article |
| id | doaj-art-55adb75b34e24e6d9be5631c28d2048f |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-55adb75b34e24e6d9be5631c28d2048f2025-02-03T01:10:30ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/894817894817IQGAP Family Members in Yeast, Dictyostelium, and Mammalian CellsKatie B. Shannon0Department of Biological Sciences, Missouri University of Science and Technology, Rolla, MO 65409, USAIQGAPs are a family of scaffolding proteins with multiple domains, named for the IQ motifs and GTPase activating protein (GAP) related domains. Despite their GAP homology, IQGAP proteins act as effectors for GTP-bound GTPases of the Ras superfamily and do not stimulate GTP hydrolysis. IQGAPs are found in eukaryotic cells from yeast to human, and localize to actin-containing structures such as lamellipodia, membrane ruffles, cell-cell adhesions, phagocytic cups, and the actomyosin ring formed during cytokinesis. Mammalian IQGAPs also act as scaffolds for signaling pathways. IQGAPs perform their myriad functions through association with a large number of proteins including filamentous actin (F-actin), GTPases, calcium-binding proteins, microtubule binding proteins, kinases, and receptors. The focus of this paper is on recent studies describing new binding partners, mechanisms of regulation, and biochemical and physiological functions of IQGAPs in yeast, amoeba, and mammalian cells.http://dx.doi.org/10.1155/2012/894817 |
| spellingShingle | Katie B. Shannon IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells International Journal of Cell Biology |
| title | IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells |
| title_full | IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells |
| title_fullStr | IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells |
| title_full_unstemmed | IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells |
| title_short | IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells |
| title_sort | iqgap family members in yeast dictyostelium and mammalian cells |
| url | http://dx.doi.org/10.1155/2012/894817 |
| work_keys_str_mv | AT katiebshannon iqgapfamilymembersinyeastdictyosteliumandmammaliancells |