HIV-1 Gag-protease-driven replicative capacity influences T-cell metabolism, cytokine induction, and viral cell-to-cell spread

HIV-1 Gag-protease-driven replicative capacity influences T-cell metabolism, cytokine induction, and viral cell-to-cell spread

ABSTRACT High replicative capacity (RC) HIV-1 strains are associated with elevated viral loads and faster disease progression in the absence of antiretroviral therapy. Understanding the mechanisms by which high RC strains adversely affect the host is essential for developing novel anti-HIV intervent...

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Main Authors: Omolara O. Baiyegunhi, Kensane Mthembu, Ann-Kathrin Reuschl, Doty Ojwach, Omotayo Farinre, Murunwa Maimela, Sheila Balinda, Matt Price, Madeleine J. Bunders, Marcus Altfeld, Clare Jolly, Jaclyn Mann, Thumbi Ndung’u
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
HIV
Gag
replicative capacity
T-cell
metabolism
subtypes
Online Access:https://journals.asm.org/doi/10.1128/mbio.03565-24
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https://journals.asm.org/doi/10.1128/mbio.03565-24

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