HPLC-MS standardization and validation methods for determination of calactin content in dichloromethane fraction of Calotropis gigantea (L.) Dryand. (Niu jiao gua) stem bark and its application in prediction of anticancer activities

HPLC-MS standardization and validation methods for determination of calactin content in dichloromethane fraction of Calotropis gigantea (L.) Dryand. (Niu jiao gua) stem bark and its application in prediction of anticancer activities

Calactin, a doubly-linked cardenolide, is commonly found in Apocynaceae family including Calotropis gigantea (L.) Dryand. (Niu jiao gua, C. gigantea). This phytochemical has gained recognition for its potential as an anticancer agent and a marker for anticancer properties. Our previous reports demon...

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Bibliographic Details
Main Authors: Naphat Kaewpaeng, Sudaporn Wongwan, Khemmachat Pansooksan, Chanakan Chailom, Pattaraporn Chaisupasakul, Dumrongsak Pekthong, Nitra Nuengchamnong, Zhi-Hong Jiang, Li-Ping Bai, Piyarat Srisawang, Supawadee Parhira
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Heliyon
Subjects:
Calotropis gigantea
Calactin
Anticancer
Standardization
Application
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025003433
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