Isolation, characterization, and genomic analysis of a novel bacteriophage vB_Kp_XP4 targeting hypervirulent and multidrug-resistant Klebsiella pneumoniae

Isolation, characterization, and genomic analysis of a novel bacteriophage vB_Kp_XP4 targeting hypervirulent and multidrug-resistant Klebsiella pneumoniae

IntroductionHypervirulent and multidrug-resistant Klebsiella pneumoniae (hvKP and MDR-KP) are significant public health threats. This study aimed to isolate a lytic bacteriophage targeting these high-risk strains, systematically characterize its biological properties, genomic features, and therapeut...

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Bibliographic Details
Main Authors: Xiaocui Peng, Jianliang Chang, Hongxia Zhang, Xiaoyu Li, Changhong Zhang, Shiyan Jiao, Chengxiu Lv, Na Wang, Jun Zhao, Bu Wang, Wei Zhang, Zhihua Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Microbiology
Subjects:
phage therapy
biological characteristics
whole-genome sequencing
Klebsiella pneumoniae
multidrug resistance
hypervirulence
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1491961/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1491961/full

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