Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse

Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse

Abstract Acute liver failure is a rapidly progressing, life-threatening condition most commonly caused by an overdose of acetaminophen (paracetamol). The antidote, N-acetylcysteine (NAC), has limited efficacy when liver injury is established. If acute liver damage is severe, liver failure can rapidl...

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Main Authors: Maria Elena Candela, Melisande Addison, Rhona Aird, Tak-Yung Man, Jennifer A. Cartwright, Candice Ashmore-Harris, Alastair M. Kilpatrick, Philip J. Starkey Lewis, Anna Drape, Mark Barnett, Donna Mitchell, Colin McLean, Neil McGowan, Marc Turner, James W. Dear, Stuart J. Forbes
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-025-00393-3
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https://doi.org/10.1038/s41536-025-00393-3

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