Modulation of Second Messenger Signaling in the Brain Through PDE4 and PDE5 Inhibition: Therapeutic Implications for Neurological Disorders

Modulation of Second Messenger Signaling in the Brain Through PDE4 and PDE5 Inhibition: Therapeutic Implications for Neurological Disorders

Phosphodiesterase (PDE) enzymes regulate intracellular signaling pathways crucial for brain development and the pathophysiology of neurological disorders. Among the 11 PDE subtypes, PDE4 and PDE5 are particularly significant due to their regulation of cyclic adenosine monophosphate (cAMP) and cyclic...

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Bibliographic Details
Main Authors: Min Kyu Park, Hyun Wook Yang, Seo Young Woo, Dong Yeon Kim, Dae-Soon Son, Bo Young Choi, Sang Won Suh
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
phosphodiesterase (PDE)
phosphodiesterase 4 (PDE4)
phosphodiesterase 5 (PDE5)
protein kinase A (PKA)
protein kinase G (PKG)
Online Access:https://www.mdpi.com/2073-4409/14/2/86
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