Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort Study
Objectives. The aim of the study was to investigate whether the use of the antifolate antibiotic trimethoprim during the 12 weeks before conception was associated with congenital malformations. Methods. We conducted a nationwide register-based cohort study including all Danish women giving birth fro...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2013/364526 |
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| author | Jon Trærup Andersen Morten Petersen Espen Jimenez-Solem Jeppe Nørgaard Rasmussen Nadia Lyhne Andersen Shoaib Afzal Kasper Broedbaek Brian Rafn Hjelvang Lars Køber Christian Torp-Pedersen Henrik Enghusen Poulsen |
| author_facet | Jon Trærup Andersen Morten Petersen Espen Jimenez-Solem Jeppe Nørgaard Rasmussen Nadia Lyhne Andersen Shoaib Afzal Kasper Broedbaek Brian Rafn Hjelvang Lars Køber Christian Torp-Pedersen Henrik Enghusen Poulsen |
| author_sort | Jon Trærup Andersen |
| collection | DOAJ |
| description | Objectives. The aim of the study was to investigate whether the use of the antifolate antibiotic trimethoprim during the 12 weeks before conception was associated with congenital malformations. Methods. We conducted a nationwide register-based cohort study including all Danish women giving birth from 1997 to 2004. All women with at least one prescription of trimethoprim dispensed during the 12 weeks before conception were identified. Results. There was a doubling of congenital malformations in offspring to women exposed to trimethoprim in the 12 weeks before conception. The adjusted odds ratio (OR) of major congenital malformation was 1.87, 95% confidence interval (CI) 1.25–2.81. There was a significant increase in major malformations of the heart (OR=2.49; 1.18–5.26) and limbs (OR=2.18; 1.13–4.23). Conclusions. In this study, we found an association between exposure to trimethoprim during the 12 weeks before conception and an increased risk of heart and limb defects. |
| format | Article |
| id | doaj-art-552c0c7a779443d89b4faa2b8c639945 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-552c0c7a779443d89b4faa2b8c6399452025-02-03T01:21:11ZengWileyObstetrics and Gynecology International1687-95891687-95972013-01-01201310.1155/2013/364526364526Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort StudyJon Trærup Andersen0Morten Petersen1Espen Jimenez-Solem2Jeppe Nørgaard Rasmussen3Nadia Lyhne Andersen4Shoaib Afzal5Kasper Broedbaek6Brian Rafn Hjelvang7Lars Køber8Christian Torp-Pedersen9Henrik Enghusen Poulsen10Laboratory of Clinical Pharmacology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, DenmarkLaboratory of Clinical Pharmacology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, DenmarkLaboratory of Clinical Pharmacology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, DenmarkCenter for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, DenmarkMental Health Centre Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen, DenmarkLaboratory of Clinical Pharmacology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, DenmarkLaboratory of Clinical Pharmacology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, DenmarkLaboratory of Clinical Pharmacology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, DenmarkThe Heart Centre, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, DenmarkDepartment of Cardiology, Gentofte University Hospital, Niels Andersens Vej 65, 2900 Hellerup, DenmarkLaboratory of Clinical Pharmacology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, DenmarkObjectives. The aim of the study was to investigate whether the use of the antifolate antibiotic trimethoprim during the 12 weeks before conception was associated with congenital malformations. Methods. We conducted a nationwide register-based cohort study including all Danish women giving birth from 1997 to 2004. All women with at least one prescription of trimethoprim dispensed during the 12 weeks before conception were identified. Results. There was a doubling of congenital malformations in offspring to women exposed to trimethoprim in the 12 weeks before conception. The adjusted odds ratio (OR) of major congenital malformation was 1.87, 95% confidence interval (CI) 1.25–2.81. There was a significant increase in major malformations of the heart (OR=2.49; 1.18–5.26) and limbs (OR=2.18; 1.13–4.23). Conclusions. In this study, we found an association between exposure to trimethoprim during the 12 weeks before conception and an increased risk of heart and limb defects.http://dx.doi.org/10.1155/2013/364526 |
| spellingShingle | Jon Trærup Andersen Morten Petersen Espen Jimenez-Solem Jeppe Nørgaard Rasmussen Nadia Lyhne Andersen Shoaib Afzal Kasper Broedbaek Brian Rafn Hjelvang Lars Køber Christian Torp-Pedersen Henrik Enghusen Poulsen Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort Study Obstetrics and Gynecology International |
| title | Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort Study |
| title_full | Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort Study |
| title_fullStr | Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort Study |
| title_full_unstemmed | Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort Study |
| title_short | Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort Study |
| title_sort | trimethoprim use prior to pregnancy and the risk of congenital malformation a register based nationwide cohort study |
| url | http://dx.doi.org/10.1155/2013/364526 |
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