Immunogenicity and safety of an Entamoeba histolytica adjuvanted protein vaccine candidate (LecA+GLA-3M-052 liposomes) in rhesus macaques

Immunogenicity and safety of an Entamoeba histolytica adjuvanted protein vaccine candidate (LecA+GLA-3M-052 liposomes) in rhesus macaques

Entamoeba histolytica, the causative agent of amebiasis, is one of the top three parasitic causes of mortality worldwide. However, no vaccine exists against amebiasis. Using a lead candidate vaccine containing the LecA fragment of Gal-lectin and GLA-3M-052 liposome adjuvant, we immunized rhesus maca...

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Main Authors: Mayuresh M. Abhyankar, Feifan Xu, Deborah Chavez, Anna Goodroe, Elda Mendoza, Christopher Chen, Dhiraj K. Singh, Fernando Varnador, Sandra J. Sivananthan, Robert Kinsey, William R. Lykins, Brynn M. Murphy, Andrew R. Martin, Mark A. Tomai, Soutik Ghosal, Corey Casper, Karl Pedersen, William A. Petri, Christopher B. Fox
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Entamoeba histolytica
rhesus macaque
mucosal adjuvant
intranasal delivery
amebiasis
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2024.2374147
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https://www.tandfonline.com/doi/10.1080/21645515.2024.2374147

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