Causal relationship between body mass index and insulin resistance: Linear and nonlinear Mendelian randomization study in a Japanese population

Causal relationship between body mass index and insulin resistance: Linear and nonlinear Mendelian randomization study in a Japanese population

ABSTRACT Aims/Introduction Obesity is a known risk factor for several chronic diseases, including type 2 diabetes mellitus, which results from increased insulin resistance and impaired insulin secretion. However, the association between obesity and insulin resistance in Asian populations has not yet...

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Main Authors: Noriyuki Ishida, Sei Harada, Ryota Toki, Aya Hirata, Minako Matsumoto, Naoko Miyagawa, Miho Iida, Shun Edagawa, Atsuko Miyake, Kazuyo Kuwabara, Takuma Shibuki, Suzuka Kato, Kazuharu Arakawa, Kengo Kinoshita, Mika Sakurai‐Yageta, Gen Tamiya, Kengo Nagashima, Hirokazu Muraoka, Yasunori Sato, Toru Takebayashi
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Journal of Diabetes Investigation
Subjects:
Body mass index
Insulin resistance
Mendelian randomization analysis
Online Access:https://doi.org/10.1111/jdi.14377
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https://doi.org/10.1111/jdi.14377

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