Synaptogenic gene therapy with FGF22 improves circuit plasticity and functional recovery following spinal cord injury

Synaptogenic gene therapy with FGF22 improves circuit plasticity and functional recovery following spinal cord injury

Abstract Functional recovery following incomplete spinal cord injury (SCI) depends on the rewiring of motor circuits during which supraspinal connections form new contacts onto spinal relay neurons. We have recently identified a critical role of the presynaptic organizer FGF22 for the formation of n...

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Main Authors: Almir Aljović, Anne Jacobi, Maite Marcantoni, Fritz Kagerer, Kristina Loy, Arek Kendirli, Jonas Bräutigam, Luca Fabbio, Valérie Van Steenbergen, Katarzyna Pleśniar, Martin Kerschensteiner, Florence M Bareyre
Format: Article
Language:English
Published: Springer Nature 2023-01-01
Series:EMBO Molecular Medicine
Subjects:
adeno‐associated virus
FGF22
gene therapy
recovery
spinal cord injury
Online Access:https://doi.org/10.15252/emmm.202216111
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https://doi.org/10.15252/emmm.202216111

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