Preclinical evaluation of the potential PARP-imaging probe [carbonyl-11C]DPQ

Preclinical evaluation of the potential PARP-imaging probe [carbonyl-11C]DPQ

Abstract Background Poly (ADP-ribose) polymerase (PARP) enzymes are crucial for the repair of DNA single-strand breaks and have become key therapeutic targets in homologous recombination-deficient cancers, including prostate cancer. To enable non-invasive monitoring of PARP-1 expression, several PAR...

Full description

Saved in:
Bibliographic Details
Main Authors: Katarína Benčurová, Theresa Balber, Victoria Weissenböck, Lukas Kogler, Joachim Friske, Verena Pichler, Markus Mitterhauser, Marcus Hacker, Cécile Philippe, Marius Ozenil
Format: Article
Language:English
Published: SpringerOpen 2025-01-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
PARP-1
DPQ
PET
Tracer
C-11
Preclinical evaluation
Online Access:https://doi.org/10.1186/s41181-024-00323-6
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s41181-024-00323-6

Similar Items