A new attenuated and highly immunogenic orthopoxvirus vaccine protects against mpox in mice and macaques

A new attenuated and highly immunogenic orthopoxvirus vaccine protects against mpox in mice and macaques

Abstract Shortly after 2022, mpox again becomes a public health emergency of international concern as declared by the World Health Organization on August 14, 2024. Smallpox vaccines ACAM2000 and MVA-BN were approved for mpox prevention in several countries. However, the side effects of ACAM2000 and...

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Main Authors: Fengwen Xu, Yu Huang, Yongzhi Hou, Yu Xie, Baoying Huang, Fei Zhao, Zhao Gao, Chen Chen, Jiaxun Wang, Shan Mei, Yamei Hu, Liming Wang, Liang Wei, Jingjing Zhang, Na Li, Zhe Cong, Jianrong Ma, Lin Zhu, Ting Chen, Jiahan Lu, Qiang Wei, Wenjie Tan, Jing Xue, Fei Guo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01193-y
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https://doi.org/10.1038/s41541-025-01193-y

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