Investigation of IL-17A Serum Levels in Patients with Nonmelanoma Skin Cancer
Background. Role of interleukin 17A (IL-17A) in carcinogenesis and cancer growth is controversial. Although some researches support its antitumor activity, some others suggest that it promotes the growth and development of different types of cancer including skin cancer by activation of STAT3. Altho...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/5540163 |
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| author | Mehdi Ghahartars Fatemeh Sedaghat Elham Khajavi Amir Ali Nejat Mahyar Malekzadeh Abbas Ghaderi Mohammad Javad Fattahi |
| author_facet | Mehdi Ghahartars Fatemeh Sedaghat Elham Khajavi Amir Ali Nejat Mahyar Malekzadeh Abbas Ghaderi Mohammad Javad Fattahi |
| author_sort | Mehdi Ghahartars |
| collection | DOAJ |
| description | Background. Role of interleukin 17A (IL-17A) in carcinogenesis and cancer growth is controversial. Although some researches support its antitumor activity, some others suggest that it promotes the growth and development of different types of cancer including skin cancer by activation of STAT3. Although the function of the cytokines such as IL-17A has been extensively studied in various types of cancer, nonmelanoma skin cancer (NMSC) has not received much attention. Therefore, the present study was aimed to investigate the serum levels of IL-17A in NMSC patients. Methods. This cross-sectional study was performed on 60 patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) as well as 57 age-sex matched healthy individuals as control group. Measurement of IL-17A serum levels in both case and control groups was performed by a commercially reliable sandwich enzyme-linked immunosorbent assay (ELISA) kit. Results. In this study, we observed that IL-17A serum levels in NMSC patients were significantly higher than the control group P<0.001. Also, both BCC and SCC patients had higher levels of IL-17A in their sera in comparison to the controls (P=0.001 and P<0.001, respectively). However, there was no significant difference between SCC and BCC patients regarding serum levels of IL-17A. Conclusion. According to our results, it can be concluded that IL-17A may play a role in inducing the growth and progression of NMSC and it can be used as a therapeutic target in these patients in future. |
| format | Article |
| id | doaj-art-54d93eaa5aa642b6a45370a72d45e34e |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-54d93eaa5aa642b6a45370a72d45e34e2025-02-03T01:24:42ZengWileyDermatology Research and Practice1687-61051687-61132021-01-01202110.1155/2021/55401635540163Investigation of IL-17A Serum Levels in Patients with Nonmelanoma Skin CancerMehdi Ghahartars0Fatemeh Sedaghat1Elham Khajavi2Amir Ali Nejat3Mahyar Malekzadeh4Abbas Ghaderi5Mohammad Javad Fattahi6Department of Dermatology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranBackground. Role of interleukin 17A (IL-17A) in carcinogenesis and cancer growth is controversial. Although some researches support its antitumor activity, some others suggest that it promotes the growth and development of different types of cancer including skin cancer by activation of STAT3. Although the function of the cytokines such as IL-17A has been extensively studied in various types of cancer, nonmelanoma skin cancer (NMSC) has not received much attention. Therefore, the present study was aimed to investigate the serum levels of IL-17A in NMSC patients. Methods. This cross-sectional study was performed on 60 patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) as well as 57 age-sex matched healthy individuals as control group. Measurement of IL-17A serum levels in both case and control groups was performed by a commercially reliable sandwich enzyme-linked immunosorbent assay (ELISA) kit. Results. In this study, we observed that IL-17A serum levels in NMSC patients were significantly higher than the control group P<0.001. Also, both BCC and SCC patients had higher levels of IL-17A in their sera in comparison to the controls (P=0.001 and P<0.001, respectively). However, there was no significant difference between SCC and BCC patients regarding serum levels of IL-17A. Conclusion. According to our results, it can be concluded that IL-17A may play a role in inducing the growth and progression of NMSC and it can be used as a therapeutic target in these patients in future.http://dx.doi.org/10.1155/2021/5540163 |
| spellingShingle | Mehdi Ghahartars Fatemeh Sedaghat Elham Khajavi Amir Ali Nejat Mahyar Malekzadeh Abbas Ghaderi Mohammad Javad Fattahi Investigation of IL-17A Serum Levels in Patients with Nonmelanoma Skin Cancer Dermatology Research and Practice |
| title | Investigation of IL-17A Serum Levels in Patients with Nonmelanoma Skin Cancer |
| title_full | Investigation of IL-17A Serum Levels in Patients with Nonmelanoma Skin Cancer |
| title_fullStr | Investigation of IL-17A Serum Levels in Patients with Nonmelanoma Skin Cancer |
| title_full_unstemmed | Investigation of IL-17A Serum Levels in Patients with Nonmelanoma Skin Cancer |
| title_short | Investigation of IL-17A Serum Levels in Patients with Nonmelanoma Skin Cancer |
| title_sort | investigation of il 17a serum levels in patients with nonmelanoma skin cancer |
| url | http://dx.doi.org/10.1155/2021/5540163 |
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