Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid
Background. Most patients with a preoperative diagnosis of thyroid follicular neoplasm (FN) undergo diagnostic surgery to determine whether the nodule is benign or malignant. Point mutations at NRAS codon 61 are the most common mutations observed in FN. However, the clinical significance of NRAS mut...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/289834 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559829362671616 |
|---|---|
| author | Ja-Seong Bae Seung Kyu Choi Sora Jeon Yourha Kim Sohee Lee Youn Soo Lee Chan Kwon Jung |
| author_facet | Ja-Seong Bae Seung Kyu Choi Sora Jeon Yourha Kim Sohee Lee Youn Soo Lee Chan Kwon Jung |
| author_sort | Ja-Seong Bae |
| collection | DOAJ |
| description | Background. Most patients with a preoperative diagnosis of thyroid follicular neoplasm (FN) undergo diagnostic surgery to determine whether the nodule is benign or malignant. Point mutations at NRAS codon 61 are the most common mutations observed in FN. However, the clinical significance of NRAS mutation remains unclear. Methods. From 2012 to 2013, 123 consecutive patients undergoing thyroidectomy for FN were evaluated prospectively. Molecular analyses for NRAS codon 61 were performed with pyrosequencing. Results. The overall malignancy rate in FN was 48.8% (60/123). Of 123 FNs, 33 (26.8%) were positive for the NRAS mutation. The sensitivity, specificity, positive predictive value, and negative predictive value of a NRAS mutation-positive FN specimen to predict malignancy were 37%, 83%, 67%, and 58%, respectively. Patients with a NRAS-positive FN had a higher malignancy rate in additional thyroid nodules beyond the FN than patients with a NRAS-negative FN. The overall malignancy rate of patients with a NRAS-positive FN was significantly higher than that of patients with a NRAS-negative FN (79% versus 52%; P = 0.008). Conclusions. Determining NRAS mutation status in FN helps to improve the accuracy of thyroid cancer diagnosis and to predict cancer risk in accompanying thyroid nodules. |
| format | Article |
| id | doaj-art-54c6e5a018164f8f9d48fb1ca07f6353 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-54c6e5a018164f8f9d48fb1ca07f63532025-02-03T01:29:10ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/289834289834Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the ThyroidJa-Seong Bae0Seung Kyu Choi1Sora Jeon2Yourha Kim3Sohee Lee4Youn Soo Lee5Chan Kwon Jung6Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-gu, Seoul 137-701, Republic of KoreaDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-gu, Seoul 137-701, Republic of KoreaDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-gu, Seoul 137-701, Republic of KoreaDepartment of Surgery, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-gu, Seoul 137-701, Republic of KoreaDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-gu, Seoul 137-701, Republic of KoreaBackground. Most patients with a preoperative diagnosis of thyroid follicular neoplasm (FN) undergo diagnostic surgery to determine whether the nodule is benign or malignant. Point mutations at NRAS codon 61 are the most common mutations observed in FN. However, the clinical significance of NRAS mutation remains unclear. Methods. From 2012 to 2013, 123 consecutive patients undergoing thyroidectomy for FN were evaluated prospectively. Molecular analyses for NRAS codon 61 were performed with pyrosequencing. Results. The overall malignancy rate in FN was 48.8% (60/123). Of 123 FNs, 33 (26.8%) were positive for the NRAS mutation. The sensitivity, specificity, positive predictive value, and negative predictive value of a NRAS mutation-positive FN specimen to predict malignancy were 37%, 83%, 67%, and 58%, respectively. Patients with a NRAS-positive FN had a higher malignancy rate in additional thyroid nodules beyond the FN than patients with a NRAS-negative FN. The overall malignancy rate of patients with a NRAS-positive FN was significantly higher than that of patients with a NRAS-negative FN (79% versus 52%; P = 0.008). Conclusions. Determining NRAS mutation status in FN helps to improve the accuracy of thyroid cancer diagnosis and to predict cancer risk in accompanying thyroid nodules.http://dx.doi.org/10.1155/2014/289834 |
| spellingShingle | Ja-Seong Bae Seung Kyu Choi Sora Jeon Yourha Kim Sohee Lee Youn Soo Lee Chan Kwon Jung Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid International Journal of Endocrinology |
| title | Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid |
| title_full | Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid |
| title_fullStr | Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid |
| title_full_unstemmed | Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid |
| title_short | Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid |
| title_sort | impact of nras mutations on the diagnosis of follicular neoplasm of the thyroid |
| url | http://dx.doi.org/10.1155/2014/289834 |
| work_keys_str_mv | AT jaseongbae impactofnrasmutationsonthediagnosisoffollicularneoplasmofthethyroid AT seungkyuchoi impactofnrasmutationsonthediagnosisoffollicularneoplasmofthethyroid AT sorajeon impactofnrasmutationsonthediagnosisoffollicularneoplasmofthethyroid AT yourhakim impactofnrasmutationsonthediagnosisoffollicularneoplasmofthethyroid AT soheelee impactofnrasmutationsonthediagnosisoffollicularneoplasmofthethyroid AT younsoolee impactofnrasmutationsonthediagnosisoffollicularneoplasmofthethyroid AT chankwonjung impactofnrasmutationsonthediagnosisoffollicularneoplasmofthethyroid |