Intranasal application of a bifunctional pertactin-RTX fusion antigen elicits protection of mouse airway mucosa against Bordetella pertussis colonization

Intranasal application of a bifunctional pertactin-RTX fusion antigen elicits protection of mouse airway mucosa against Bordetella pertussis colonization

ABSTRACT The adenylate cyclase toxin (ACT, AC-Hly, or CyaA) plays a key role in airway infections by Bordetella pertussis and ablates the oxidative burst and opsonophagocytic capacity of sentinel phagocytes. CyaA fragments eliciting toxin-neutralizing antibodies are considered prime antigen candidat...

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Main Authors: Carlos Espinosa-Vinals, Jana Holubova, Ondrej Stanek, Radim Osicka, Jiri Masin, Fresia Esther Arellano Herencia, Peter Sebo
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mSphere
Subjects:
Bordetella pertussis
adenylate cyclase toxin
pertactin
whooping cough
pertussis
protein folding
Online Access:https://journals.asm.org/doi/10.1128/msphere.00959-24
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https://journals.asm.org/doi/10.1128/msphere.00959-24

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