Unveiling Isorhapontigenin’s therapeutic potential in lung cancer via integrated network pharmacology, molecular docking, and experimental validation

Abstract Isorhapontigenin is an effective active ingredient in Rheum officinale, which has been reported to have anti-tumor effects. However, its effect and molecular mechanism on non-small cell lung cancer are still unclear. Firstly, potential therapeutic targets of Isorhapontigenin against non-sma...

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Bibliographic Details
Main Authors: Zhiyu Wu, Chengyu Hou, Qiulin Zhu, Zixia Huang, Zesheng Lu, Chunhui Shen, Zhenhui Wang, Yanzhong Liu, Yanfen Kang, JiYong Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-01648-1
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