Immunomodulatory Effects Mediated by Dopamine
Dopamine (DA), a neurotransmitter in the central nervous system (CNS), has modulatory functions at the systemic level. The peripheral and central nervous systems have independent dopaminergic system (DAS) that share mechanisms and molecular machinery. In the past century, experimental evidence has a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/3160486 |
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| author | Rodrigo Arreola Samantha Alvarez-Herrera Gilberto Pérez-Sánchez Enrique Becerril-Villanueva Carlos Cruz-Fuentes Enrique Octavio Flores-Gutierrez María Eugenia Garcés-Alvarez Dora Luz de la Cruz-Aguilera Emilio Medina-Rivero Gabriela Hurtado-Alvarado Saray Quintero-Fabián Lenin Pavón |
| author_facet | Rodrigo Arreola Samantha Alvarez-Herrera Gilberto Pérez-Sánchez Enrique Becerril-Villanueva Carlos Cruz-Fuentes Enrique Octavio Flores-Gutierrez María Eugenia Garcés-Alvarez Dora Luz de la Cruz-Aguilera Emilio Medina-Rivero Gabriela Hurtado-Alvarado Saray Quintero-Fabián Lenin Pavón |
| author_sort | Rodrigo Arreola |
| collection | DOAJ |
| description | Dopamine (DA), a neurotransmitter in the central nervous system (CNS), has modulatory functions at the systemic level. The peripheral and central nervous systems have independent dopaminergic system (DAS) that share mechanisms and molecular machinery. In the past century, experimental evidence has accumulated on the proteins knowledge that is involved in the synthesis, reuptake, and transportation of DA in leukocytes and the differential expression of the D1-like (D1R and D5R) and D2-like receptors (D2R, D3R, and D4R). The expression of these components depends on the state of cellular activation and the concentration and time of exposure to DA. Receptors that are expressed in leukocytes are linked to signaling pathways that are mediated by changes in cAMP concentration, which in turn triggers changes in phenotype and cellular function. According to the leukocyte lineage, the effects of DA are associated with such processes as respiratory burst, cytokine and antibody secretion, chemotaxis, apoptosis, and cytotoxicity. In clinical conditions such as schizophrenia, Parkinson disease, Tourette syndrome, and multiple sclerosis (MS), there are evident alterations during immune responses in leukocytes, in which changes in DA receptor density have been observed. Several groups have proposed that these findings are useful in establishing clinical status and clinical markers. |
| format | Article |
| id | doaj-art-546c43e2c3874d96a35e1c2f84a4422b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-546c43e2c3874d96a35e1c2f84a4422b2025-02-03T01:31:58ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/31604863160486Immunomodulatory Effects Mediated by DopamineRodrigo Arreola0Samantha Alvarez-Herrera1Gilberto Pérez-Sánchez2Enrique Becerril-Villanueva3Carlos Cruz-Fuentes4Enrique Octavio Flores-Gutierrez5María Eugenia Garcés-Alvarez6Dora Luz de la Cruz-Aguilera7Emilio Medina-Rivero8Gabriela Hurtado-Alvarado9Saray Quintero-Fabián10Lenin Pavón11Psychiatric Genetics Department, National Institute of Psychiatry “Ramón de la Fuente”, Clinical Research Branch, Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, MexicoDepartment of Psychoimmunology, National Institute of Psychiatry “Ramón de la Fuente”, Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, MexicoDepartment of Psychoimmunology, National Institute of Psychiatry “Ramón de la Fuente”, Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, MexicoDepartment of Psychoimmunology, National Institute of Psychiatry “Ramón de la Fuente”, Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, MexicoPsychiatric Genetics Department, National Institute of Psychiatry “Ramón de la Fuente”, Clinical Research Branch, Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, MexicoNational Institute of Psychiatry “Ramón de la Fuente”, Clinical Research Branch, Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, MexicoDepartment of Psychoimmunology, National Institute of Psychiatry “Ramón de la Fuente”, Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, MexicoLaboratory of Neuroimmunoendocrinology, National Institute of Neurology and Neurosurgery “Manuel Velasco Suárez”, Avenida Insurgentes Sur 3877, La Fama, Tlalpan, 14269 Mexico City, MexicoUnidad de Investigación y Desarrollo, Probiomed S.A. de C.V. Cruce de Carreteras Acatzingo-Zumpahuacán S/N, 52400 Tenancingo, MEX, MexicoArea of Neurosciences, Department of Biology of Reproduction, CBS, Universidad Autonoma Metropolitana, Unidad Iztapalapa, Avenida San Rafael Atlixco No. 186, Colonia Vicentina, Iztapalapa, 09340 Mexico City, MexicoUnidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Instituto Nacional de Pediatría, Av. del Iman No. 1, Cuarto Piso, 04530 Mexico City, MexicoDepartment of Psychoimmunology, National Institute of Psychiatry “Ramón de la Fuente”, Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, MexicoDopamine (DA), a neurotransmitter in the central nervous system (CNS), has modulatory functions at the systemic level. The peripheral and central nervous systems have independent dopaminergic system (DAS) that share mechanisms and molecular machinery. In the past century, experimental evidence has accumulated on the proteins knowledge that is involved in the synthesis, reuptake, and transportation of DA in leukocytes and the differential expression of the D1-like (D1R and D5R) and D2-like receptors (D2R, D3R, and D4R). The expression of these components depends on the state of cellular activation and the concentration and time of exposure to DA. Receptors that are expressed in leukocytes are linked to signaling pathways that are mediated by changes in cAMP concentration, which in turn triggers changes in phenotype and cellular function. According to the leukocyte lineage, the effects of DA are associated with such processes as respiratory burst, cytokine and antibody secretion, chemotaxis, apoptosis, and cytotoxicity. In clinical conditions such as schizophrenia, Parkinson disease, Tourette syndrome, and multiple sclerosis (MS), there are evident alterations during immune responses in leukocytes, in which changes in DA receptor density have been observed. Several groups have proposed that these findings are useful in establishing clinical status and clinical markers.http://dx.doi.org/10.1155/2016/3160486 |
| spellingShingle | Rodrigo Arreola Samantha Alvarez-Herrera Gilberto Pérez-Sánchez Enrique Becerril-Villanueva Carlos Cruz-Fuentes Enrique Octavio Flores-Gutierrez María Eugenia Garcés-Alvarez Dora Luz de la Cruz-Aguilera Emilio Medina-Rivero Gabriela Hurtado-Alvarado Saray Quintero-Fabián Lenin Pavón Immunomodulatory Effects Mediated by Dopamine Journal of Immunology Research |
| title | Immunomodulatory Effects Mediated by Dopamine |
| title_full | Immunomodulatory Effects Mediated by Dopamine |
| title_fullStr | Immunomodulatory Effects Mediated by Dopamine |
| title_full_unstemmed | Immunomodulatory Effects Mediated by Dopamine |
| title_short | Immunomodulatory Effects Mediated by Dopamine |
| title_sort | immunomodulatory effects mediated by dopamine |
| url | http://dx.doi.org/10.1155/2016/3160486 |
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