Akkermansia muciniphila Mediated the Preventive Effect of Disulfiram on Acute Liver Injury via PI3K/Akt Pathway

Akkermansia muciniphila Mediated the Preventive Effect of Disulfiram on Acute Liver Injury via PI3K/Akt Pathway

ABSTRACT Acetaminophen induced acute liver injury (ALI) has a high incidence and is a serious medical problem, but there is a lack of effective treatment. The enterohepatic axis is one of the targets of recent attention due to its important role in liver diseases. Disulfiram (DSF) is a multitarget d...

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Main Authors: Ruonan Zhang, Xuewei Sun, Han Lu, Xinrui Zhang, Mingyan Zhang, Xuewen Ji, Xinyi Yu, Chengliang Tang, Zihan Wu, Yinghua Mao, Jin Zhu, Minjun Ji, Zhan Yang
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Microbial Biotechnology
Subjects:
acetaminophen
acute liver injury
Akkermansia muciniphila
disulfiram
gut microbiome
PI3K/Akt pathway
Online Access:https://doi.org/10.1111/1751-7915.70083
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https://doi.org/10.1111/1751-7915.70083

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