Alterations in DNA Damage Repair Genes Before and After Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer

Alterations in DNA Damage Repair Genes Before and After Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer

Background and objective: The role of genetic variants in response to systemic therapy in muscle-invasive bladder cancer (MIBC) is still elusive. We assessed variations in genes involved in DNA damage repair (DDR) before and after cisplatin-based neoadjuvant chemotherapy (NAC) and correlation of alt...

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Bibliographic Details
Main Authors: Ursula Lemberger, Büsra Ernhofer, Sigurd Krieger, Andreas Bruchbacher, André Oszwald, Ekaterina Laukhtina, Andrea Haitl, Melanie R. Hassler, Bernhard Englinger, Eva Compérat, Shahrokh F. Shariat
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:European Urology Open Science
Subjects:
Cisplatin-based neoadjuvant chemotherapy
DNA repair genes
Mutation
Muscle-invasive bladder cancer
Next-generation sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2666168324014137
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