Combined single-cell RNA-seq and bulk RNA-seq construction of M2 TAMs signature for predicting HNSCC prognosis and immunotherapy

Combined single-cell RNA-seq and bulk RNA-seq construction of M2 TAMs signature for predicting HNSCC prognosis and immunotherapy

Tumor associated macrophages (TAMs) in Head and neck squamous cell carcinoma (HNSCC), particularly M2-polarized subtypes, are pivotal drivers of tumorigenesis, angiogenesis, and metastasis, contributing to adverse clinical outcomes. Current prognostic markers lack precision, underscoring the need fo...

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Bibliographic Details
Main Authors: Jiale Wang, Huan Li, Mingrui Shi, Chenghao Ren, Wu Wei, Qi Zhao, Xinxin He, Zihui Yang, Jianhua Wei, Xinjie Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
single-cell RNA sequencing
tumor-associated macrophages
head and neck squamous cell carcinoma
weighted correlation network analysis
immune profile
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1620931/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1620931/full

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