Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical Remission
The treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs) in reproductive-aged women poses major dilemmas concerning its associated teratogenicity as observed in many animal studies. Much controversy exists regarding continuation versus discontinuation of its use in preg...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/5651064 |
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| _version_ | 1832567230089396224 |
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| author | Sasha Mikhael Ashlee Pascoe Joseph Prezzato |
| author_facet | Sasha Mikhael Ashlee Pascoe Joseph Prezzato |
| author_sort | Sasha Mikhael |
| collection | DOAJ |
| description | The treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs) in reproductive-aged women poses major dilemmas concerning its associated teratogenicity as observed in many animal studies. Much controversy exists regarding continuation versus discontinuation of its use in pregnancy with some studies suggesting safety of TKIs before and during pregnancy and others reporting toxicity and adverse outcomes. TKIs have become a well-established treatment option for CML, significantly improving prognosis, and yet have been reported to be fetotoxic. We present a case of a 25-year-old woman who achieved successful pregnancy and delivery after withholding treatment, meanwhile relapsing, eventually achieving complete molecular remission after reinitiation of high dose dasatinib. |
| format | Article |
| id | doaj-art-540d4d7436824ed6bc03c2b4a77a512d |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-540d4d7436824ed6bc03c2b4a77a512d2025-02-03T01:02:01ZengWileyCase Reports in Oncological Medicine2090-67062090-67142017-01-01201710.1155/2017/56510645651064Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical RemissionSasha Mikhael0Ashlee Pascoe1Joseph Prezzato2Department of Obstetrics and Gynecology, Providence Hospital, Michigan State University College of Human Medicine, East Lansing, MI, USADepartment of Obstetrics and Gynecology, Providence Hospital, Michigan State University College of Human Medicine, East Lansing, MI, USADepartment of Obstetrics and Gynecology, Providence Hospital, Michigan State University College of Human Medicine, East Lansing, MI, USAThe treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs) in reproductive-aged women poses major dilemmas concerning its associated teratogenicity as observed in many animal studies. Much controversy exists regarding continuation versus discontinuation of its use in pregnancy with some studies suggesting safety of TKIs before and during pregnancy and others reporting toxicity and adverse outcomes. TKIs have become a well-established treatment option for CML, significantly improving prognosis, and yet have been reported to be fetotoxic. We present a case of a 25-year-old woman who achieved successful pregnancy and delivery after withholding treatment, meanwhile relapsing, eventually achieving complete molecular remission after reinitiation of high dose dasatinib.http://dx.doi.org/10.1155/2017/5651064 |
| spellingShingle | Sasha Mikhael Ashlee Pascoe Joseph Prezzato Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical Remission Case Reports in Oncological Medicine |
| title | Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical Remission |
| title_full | Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical Remission |
| title_fullStr | Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical Remission |
| title_full_unstemmed | Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical Remission |
| title_short | Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical Remission |
| title_sort | recurrence of chronic myeloid leukemia during pregnancy subsequently achieving complete medical remission |
| url | http://dx.doi.org/10.1155/2017/5651064 |
| work_keys_str_mv | AT sashamikhael recurrenceofchronicmyeloidleukemiaduringpregnancysubsequentlyachievingcompletemedicalremission AT ashleepascoe recurrenceofchronicmyeloidleukemiaduringpregnancysubsequentlyachievingcompletemedicalremission AT josephprezzato recurrenceofchronicmyeloidleukemiaduringpregnancysubsequentlyachievingcompletemedicalremission |