BDNF secreted by mesenchymal stem cells improves aged oocyte quality and development potential by activating the ERK1/2 pathway

BDNF secreted by mesenchymal stem cells improves aged oocyte quality and development potential by activating the ERK1/2 pathway

Abstract Background Reduced oocyte quality is a key factor in age-related fertility decline, and there are no effective treatments available. The secretome of mesenchymal stem cells (MSC-sec) contains various bioactive factors and has the potential to improve oocyte quality. This study aimed to inve...

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Bibliographic Details
Main Authors: Jing Zhou, Cheng Li, Xin Mi, Jiali Zhou, Caiyi Chen, Jiayi Ren, Ran Liu, Gang Liu, Zi-Jiang Chen, Yingying Qin, Keliang Wu, Shidou Zhao
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cell Communication and Signaling
Subjects:
Mesenchymal stem cells
Oocyte quality
BDNF
ERK1/2 pathway
Aneuploidy
Online Access:https://doi.org/10.1186/s12964-025-02137-8
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https://doi.org/10.1186/s12964-025-02137-8

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