How does the tea L-theanine buffer stress and anxiety

Tea (Camellia sinensis) is widely considered to promote feelings of calming and soothing. This effect is attributed to L-theanine (L-γ-glutamylethylamide) in tea, a non-protein amino acid mainly derived from tea leaves. As a naturally occurring structural analogue of glutamate, L-theanine competes f...

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Main Authors: Liwen Wang, Margaret Brennan, Shiming Li, Hui Zhao, Klaus W. Lange, Charles Brennan
Format: Article
Language:English
Published: Tsinghua University Press 2022-05-01
Series:Food Science and Human Wellness
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213453021001324
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author Liwen Wang
Margaret Brennan
Shiming Li
Hui Zhao
Klaus W. Lange
Charles Brennan
author_facet Liwen Wang
Margaret Brennan
Shiming Li
Hui Zhao
Klaus W. Lange
Charles Brennan
author_sort Liwen Wang
collection DOAJ
description Tea (Camellia sinensis) is widely considered to promote feelings of calming and soothing. This effect is attributed to L-theanine (L-γ-glutamylethylamide) in tea, a non-protein amino acid mainly derived from tea leaves. As a naturally occurring structural analogue of glutamate, L-theanine competes for the receptors with glutamate and is able to pass the blood-brain barrier to exert its relaxation effect. This review focuses on the relaxation effect of L-theanine, including animal models and the latest human trials as well as the potential molecular mechanisms regarding neuron stem cells. The biological efficacy of dietary L-theanine in the food matrix has been further discussed in this review in relation to the physiological changes in the gastrointestinal tract and bindings of L-theanine with other food components.
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series Food Science and Human Wellness
spelling doaj-art-53d9a2e5731f491cad87d0105c28568d2025-02-02T23:24:54ZengTsinghua University PressFood Science and Human Wellness2213-45302022-05-01113467475How does the tea L-theanine buffer stress and anxietyLiwen Wang0Margaret Brennan1Shiming Li2Hui Zhao3Klaus W. Lange4Charles Brennan5College of Food Science and Technology, Hebei Agricultural University, Baoding 071001, ChinaDepartment of Wine, Food and Molecular Biosciences, Lincoln University, Christchurch 7647, New ZealandHubei Key Laboratory of EFGIR, Huanggang Normal University, Huanggang 438000, China; Correspondence to: RFH076, PO Box 85084, Lincoln University, Lincoln 7647, Christchurch, New ZealandTianjin Key Laboratory of Food and Biotechnology, University of Commerce, Tianjin 300134, ChinaDepartment of Experimental Psychology, University of Regensburg, Regensburg 93040, GermanyDepartment of Wine, Food and Molecular Biosciences, Lincoln University, Christchurch 7647, New Zealand; School of Science, RMIT, Melbourne, VIC 3000, Australia; Correspondence to: Department of Food Science School of Environmental and Biological Sciences Rutgers, The State University of New Jersey 65 Dudley Road, New Brunswick, NJ 08901-8520 Fax: 732-932-6776Tea (Camellia sinensis) is widely considered to promote feelings of calming and soothing. This effect is attributed to L-theanine (L-γ-glutamylethylamide) in tea, a non-protein amino acid mainly derived from tea leaves. As a naturally occurring structural analogue of glutamate, L-theanine competes for the receptors with glutamate and is able to pass the blood-brain barrier to exert its relaxation effect. This review focuses on the relaxation effect of L-theanine, including animal models and the latest human trials as well as the potential molecular mechanisms regarding neuron stem cells. The biological efficacy of dietary L-theanine in the food matrix has been further discussed in this review in relation to the physiological changes in the gastrointestinal tract and bindings of L-theanine with other food components.http://www.sciencedirect.com/science/article/pii/S2213453021001324L-theanineRelaxationStressAnxietyFood matrix
spellingShingle Liwen Wang
Margaret Brennan
Shiming Li
Hui Zhao
Klaus W. Lange
Charles Brennan
How does the tea L-theanine buffer stress and anxiety
Food Science and Human Wellness
L-theanine
Relaxation
Stress
Anxiety
Food matrix
title How does the tea L-theanine buffer stress and anxiety
title_full How does the tea L-theanine buffer stress and anxiety
title_fullStr How does the tea L-theanine buffer stress and anxiety
title_full_unstemmed How does the tea L-theanine buffer stress and anxiety
title_short How does the tea L-theanine buffer stress and anxiety
title_sort how does the tea l theanine buffer stress and anxiety
topic L-theanine
Relaxation
Stress
Anxiety
Food matrix
url http://www.sciencedirect.com/science/article/pii/S2213453021001324
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