Sexual Transmission of XMRV: A Potential Infection Route
Although XMRV dissemination in humans is a matter of debate, the prostate of select patients seem to harbor XMRV, which raises questions about its potential route of transmission. We established a model of infection in rhesus macaques inoculated with XMRV. In spite of the intravenous inoculation, al...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2011/965689 |
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| author | Prachi Sharma Kenneth A. Rogers Suganthi Suppiah Ross J. Molinaro Nattawat Onlamoon John Hackett Gerald Schochetman Eric A. Klein Robert H. Silverman François Villinger |
| author_facet | Prachi Sharma Kenneth A. Rogers Suganthi Suppiah Ross J. Molinaro Nattawat Onlamoon John Hackett Gerald Schochetman Eric A. Klein Robert H. Silverman François Villinger |
| author_sort | Prachi Sharma |
| collection | DOAJ |
| description | Although XMRV dissemination in humans is a matter of debate, the prostate of select patients seem to harbor XMRV, which raises questions about its potential route of transmission. We established a model of infection in rhesus macaques inoculated with XMRV. In spite of the intravenous inoculation, all infected macaques exhibited readily detectable XMRV signal in the reproductive tract of all 4 males and 1 female during both acute and chronic infection stages. XMRV showed explosive growth in the acini of prostate during acute but not chronic infection. In seminal vesicles, epididymis, and testes, XMRV protein production was detected throughout infection in interstitial or epithelial cells. In the female monkey, epithelial cells in the cervix and vagina were also positive for XMRV gag. The ready detection of XMRV in the reproductive tract of male and female macaques infected intravenously suggests the potential for sexual transmission for XMRV. |
| format | Article |
| id | doaj-art-53adc33165dd47b0a5e93a5a049007d6 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-53adc33165dd47b0a5e93a5a049007d62025-02-03T01:01:40ZengWileyAdvances in Virology1687-86391687-86472011-01-01201110.1155/2011/965689965689Sexual Transmission of XMRV: A Potential Infection RoutePrachi Sharma0Kenneth A. Rogers1Suganthi Suppiah2Ross J. Molinaro3Nattawat Onlamoon4John Hackett5Gerald Schochetman6Eric A. Klein7Robert H. Silverman8François Villinger9Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USADivision of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USADepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30329, USADepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30329, USADepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30329, USAAbbott Diagnostics, Emerging Pathogens and Virus Discovery, Abbott Park, IL 60064, USAAbbott Diagnostics, Emerging Pathogens and Virus Discovery, Abbott Park, IL 60064, USAGlickman Urological and Kidney Institute and LRI, Cleveland Clinic Foundation, Cleveland, OH 44195, USALerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USADivision of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USAAlthough XMRV dissemination in humans is a matter of debate, the prostate of select patients seem to harbor XMRV, which raises questions about its potential route of transmission. We established a model of infection in rhesus macaques inoculated with XMRV. In spite of the intravenous inoculation, all infected macaques exhibited readily detectable XMRV signal in the reproductive tract of all 4 males and 1 female during both acute and chronic infection stages. XMRV showed explosive growth in the acini of prostate during acute but not chronic infection. In seminal vesicles, epididymis, and testes, XMRV protein production was detected throughout infection in interstitial or epithelial cells. In the female monkey, epithelial cells in the cervix and vagina were also positive for XMRV gag. The ready detection of XMRV in the reproductive tract of male and female macaques infected intravenously suggests the potential for sexual transmission for XMRV.http://dx.doi.org/10.1155/2011/965689 |
| spellingShingle | Prachi Sharma Kenneth A. Rogers Suganthi Suppiah Ross J. Molinaro Nattawat Onlamoon John Hackett Gerald Schochetman Eric A. Klein Robert H. Silverman François Villinger Sexual Transmission of XMRV: A Potential Infection Route Advances in Virology |
| title | Sexual Transmission of XMRV: A Potential Infection Route |
| title_full | Sexual Transmission of XMRV: A Potential Infection Route |
| title_fullStr | Sexual Transmission of XMRV: A Potential Infection Route |
| title_full_unstemmed | Sexual Transmission of XMRV: A Potential Infection Route |
| title_short | Sexual Transmission of XMRV: A Potential Infection Route |
| title_sort | sexual transmission of xmrv a potential infection route |
| url | http://dx.doi.org/10.1155/2011/965689 |
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