Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection

Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection

Abstract SARS‐CoV‐2, the agent that causes COVID‐19, invades epithelial cells, including those of the respiratory and gastrointestinal mucosa, using angiotensin‐converting enzyme‐2 (ACE2) as a receptor. Subsequent inflammation can promote rapid virus clearance, but severe cases of COVID‐19 are chara...

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Bibliographic Details
Main Authors: Julian Heuberger, Jakob Trimpert, Daria Vladimirova, Christian Goosmann, Manqiang Lin, Rosa Schmuck, Hans‐Joachim Mollenkopf, Volker Brinkmann, Frank Tacke, Nikolaus Osterrieder, Michael Sigal
Format: Article
Language:English
Published: Springer Nature 2021-03-01
Series:EMBO Molecular Medicine
Subjects:
ACE2
differentiation
interferon
organoids
SARS‐CoV‐2
Online Access:https://doi.org/10.15252/emmm.202013191
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https://doi.org/10.15252/emmm.202013191

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