Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends

Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends

<b>Background/Objectives:</b> This study evaluates the efficacy of twin screw melt granulation (TSMG), and hot-melt extrusion (HME) techniques in enhancing the solubility and dissolution of simvastatin (SIM), a poorly water-soluble drug with low bioavailability. Additionally, the study e...

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Bibliographic Details
Main Authors:	Rasha M. Elkanayati, Indrajeet Karnik, Prateek Uttreja, Nagarjuna Narala, Sateesh Kumar Vemula, Krizia Karry, Michael A. Repka
Format:	Article
Language:	English
Published:	MDPI AG 2024-12-01
Series:	Pharmaceutics
Subjects:	twin screw melt granulation hot-melt extrusion amorphous solid dispersion Soluplus Kollicoat IR solubility enhancement
Online Access:	https://www.mdpi.com/1999-4923/16/12/1630
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