Fluorescence-Guided Resection of Malignant Glioma with 5-ALA
Malignant gliomas are extremely difficult to treat with no specific curative treatment. On the other hand, photodynamic medicine represents a promising technique for neurosurgeons in the treatment of malignant glioma. The resection rate of malignant glioma has increased from 40% to 80% owing to 5-am...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2016/6135293 |
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| author | Sadahiro Kaneko Sadao Kaneko |
| author_facet | Sadahiro Kaneko Sadao Kaneko |
| author_sort | Sadahiro Kaneko |
| collection | DOAJ |
| description | Malignant gliomas are extremely difficult to treat with no specific curative treatment. On the other hand, photodynamic medicine represents a promising technique for neurosurgeons in the treatment of malignant glioma. The resection rate of malignant glioma has increased from 40% to 80% owing to 5-aminolevulinic acid-photodynamic diagnosis (ALA-PDD). Furthermore, ALA is very useful because it has no serious complications. Based on previous research, it is apparent that protoporphyrin IX (PpIX) accumulates abundantly in malignant glioma tissues after ALA administration. Moreover, it is evident that the mechanism underlying PpIX accumulation in malignant glioma tissues involves an abnormality in porphyrin-heme metabolism, specifically decreased ferrochelatase enzyme activity. During resection surgery, the macroscopic fluorescence of PpIX to the naked eye is more sensitive than magnetic resonance imaging, and the alert real time spectrum of PpIX is the most sensitive method. In the future, chemotherapy with new anticancer agents, immunotherapy, and new methods of radiotherapy and gene therapy will be developed; however, ALA will play a key role in malignant glioma treatment before the development of these new treatments. In this paper, we provide an overview and present the results of our clinical research on ALA-PDD. |
| format | Article |
| id | doaj-art-5373b4f8c13541f49dbce71f19b0c4cb |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-5373b4f8c13541f49dbce71f19b0c4cb2025-02-03T01:30:36ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962016-01-01201610.1155/2016/61352936135293Fluorescence-Guided Resection of Malignant Glioma with 5-ALASadahiro Kaneko0Sadao Kaneko1Department of Neurosurgery, Tomakomai City Hospital, No. 5-20, 1-chome, Shimizutyou, Tomakomai, Hokkaido 053-0034, JapanDepartment of Neurosurgery, Kashiwaba Neurosurgical Hospital, No. 7-20, 15-chome, 1-jyou, Tsukisamuhigashi, Toyohira-ku, Sapporo, Hokkaido 062-5813, JapanMalignant gliomas are extremely difficult to treat with no specific curative treatment. On the other hand, photodynamic medicine represents a promising technique for neurosurgeons in the treatment of malignant glioma. The resection rate of malignant glioma has increased from 40% to 80% owing to 5-aminolevulinic acid-photodynamic diagnosis (ALA-PDD). Furthermore, ALA is very useful because it has no serious complications. Based on previous research, it is apparent that protoporphyrin IX (PpIX) accumulates abundantly in malignant glioma tissues after ALA administration. Moreover, it is evident that the mechanism underlying PpIX accumulation in malignant glioma tissues involves an abnormality in porphyrin-heme metabolism, specifically decreased ferrochelatase enzyme activity. During resection surgery, the macroscopic fluorescence of PpIX to the naked eye is more sensitive than magnetic resonance imaging, and the alert real time spectrum of PpIX is the most sensitive method. In the future, chemotherapy with new anticancer agents, immunotherapy, and new methods of radiotherapy and gene therapy will be developed; however, ALA will play a key role in malignant glioma treatment before the development of these new treatments. In this paper, we provide an overview and present the results of our clinical research on ALA-PDD.http://dx.doi.org/10.1155/2016/6135293 |
| spellingShingle | Sadahiro Kaneko Sadao Kaneko Fluorescence-Guided Resection of Malignant Glioma with 5-ALA International Journal of Biomedical Imaging |
| title | Fluorescence-Guided Resection of Malignant Glioma with 5-ALA |
| title_full | Fluorescence-Guided Resection of Malignant Glioma with 5-ALA |
| title_fullStr | Fluorescence-Guided Resection of Malignant Glioma with 5-ALA |
| title_full_unstemmed | Fluorescence-Guided Resection of Malignant Glioma with 5-ALA |
| title_short | Fluorescence-Guided Resection of Malignant Glioma with 5-ALA |
| title_sort | fluorescence guided resection of malignant glioma with 5 ala |
| url | http://dx.doi.org/10.1155/2016/6135293 |
| work_keys_str_mv | AT sadahirokaneko fluorescenceguidedresectionofmalignantgliomawith5ala AT sadaokaneko fluorescenceguidedresectionofmalignantgliomawith5ala |