Cotrimoxazole-Resistant Escherichia coli Bacteremia in Neutropenic Patients at a Regional Oncology Hospital
In a regional oncology hospital using cotrimoxazole (trimethoprim-sulphamethoxazole) prophylaxis during chemotherapy-induced neutropenia, a single strain of Escherichia coli (indole negative) caused 15 of 27 episodes of Gram-negative rod bacteremia in 1987, and four of 32 such episodes in 1988. This...
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1992/140845 |
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| _version_ | 1832565018527268864 |
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| author | Daniel B Gregson Anne G Matlow Andrew E Simor Peter G Tuffnell Donald E Low Ronald Feld James E Brunton |
| author_facet | Daniel B Gregson Anne G Matlow Andrew E Simor Peter G Tuffnell Donald E Low Ronald Feld James E Brunton |
| author_sort | Daniel B Gregson |
| collection | DOAJ |
| description | In a regional oncology hospital using cotrimoxazole (trimethoprim-sulphamethoxazole) prophylaxis during chemotherapy-induced neutropenia, a single strain of Escherichia coli (indole negative) caused 15 of 27 episodes of Gram-negative rod bacteremia in 1987, and four of 32 such episodes in 1988. This biotype had not been recovered in 1986. Investigations during this ‘outbreak’ of bacteremias revealed enteric colonization with this strain of E coli in 37% of patients on leukemia or bone marrow transplant wards and in several staff members in July 1987. In 1988, 11 of 32 Gram-negative rod bacteremias were secondary to other strains of indole positive E coli of several different biotypes and plasmid profiles. Indole negative strains all exhibited low level trimethoprim resistance, whereas indole positive strains which subsequently appeared exhibited high level trimethoprim resistance. Failure of cotrimoxazole prophylaxis was initially due to the clonal dissemination of a single strain of E coli within the institution, with the subsequent appearance of multiple E coli strains with probable differing genetic bases for their resistance. |
| format | Article |
| id | doaj-art-53576c19e0a74608a76e79642961aefc |
| institution | Kabale University |
| issn | 1180-2332 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-53576c19e0a74608a76e79642961aefc2025-02-03T01:09:31ZengWileyCanadian Journal of Infectious Diseases1180-23321992-01-0131141810.1155/1992/140845Cotrimoxazole-Resistant Escherichia coli Bacteremia in Neutropenic Patients at a Regional Oncology HospitalDaniel B Gregson0Anne G Matlow1Andrew E Simor2Peter G Tuffnell3Donald E Low4Ronald Feld5James E Brunton6Departments of Medicine and Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaDepartments of Medicine and Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaDepartments of Medicine and Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada Princess Margaret Hospital, University of Toronto, Toronto, Ontario, CanadaDepartments of Medicine and Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaDepartments of Medicine and Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaUniversity of Toronto, Toronto, Ontario, CanadaIn a regional oncology hospital using cotrimoxazole (trimethoprim-sulphamethoxazole) prophylaxis during chemotherapy-induced neutropenia, a single strain of Escherichia coli (indole negative) caused 15 of 27 episodes of Gram-negative rod bacteremia in 1987, and four of 32 such episodes in 1988. This biotype had not been recovered in 1986. Investigations during this ‘outbreak’ of bacteremias revealed enteric colonization with this strain of E coli in 37% of patients on leukemia or bone marrow transplant wards and in several staff members in July 1987. In 1988, 11 of 32 Gram-negative rod bacteremias were secondary to other strains of indole positive E coli of several different biotypes and plasmid profiles. Indole negative strains all exhibited low level trimethoprim resistance, whereas indole positive strains which subsequently appeared exhibited high level trimethoprim resistance. Failure of cotrimoxazole prophylaxis was initially due to the clonal dissemination of a single strain of E coli within the institution, with the subsequent appearance of multiple E coli strains with probable differing genetic bases for their resistance.http://dx.doi.org/10.1155/1992/140845 |
| spellingShingle | Daniel B Gregson Anne G Matlow Andrew E Simor Peter G Tuffnell Donald E Low Ronald Feld James E Brunton Cotrimoxazole-Resistant Escherichia coli Bacteremia in Neutropenic Patients at a Regional Oncology Hospital Canadian Journal of Infectious Diseases |
| title | Cotrimoxazole-Resistant Escherichia coli Bacteremia in Neutropenic Patients at a Regional Oncology Hospital |
| title_full | Cotrimoxazole-Resistant Escherichia coli Bacteremia in Neutropenic Patients at a Regional Oncology Hospital |
| title_fullStr | Cotrimoxazole-Resistant Escherichia coli Bacteremia in Neutropenic Patients at a Regional Oncology Hospital |
| title_full_unstemmed | Cotrimoxazole-Resistant Escherichia coli Bacteremia in Neutropenic Patients at a Regional Oncology Hospital |
| title_short | Cotrimoxazole-Resistant Escherichia coli Bacteremia in Neutropenic Patients at a Regional Oncology Hospital |
| title_sort | cotrimoxazole resistant escherichia coli bacteremia in neutropenic patients at a regional oncology hospital |
| url | http://dx.doi.org/10.1155/1992/140845 |
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