Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in Patients Who Underwent Retropubic Radical Prostatectomy
Purpose. The purpose of this study is to investigate whether the clinicopathological biopsy findings can predict the oncological outcome in patients who undergo radical prostatectomy. Materials and Methods. Between January 1997 and March 2006, 255 patients with clinically localized adenocarcinoma of...
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| Format: | Article |
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Wiley
2012-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2012/204215 |
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| author | Nobumichi Tanaka Kiyohide Fujimoto Akihide Hirayama Yasushi Nakai Yoshitomo Chihara Satoshi Anai Atsushi Tomioka Keiji Shimada Noboru Konishi Yoshihiko Hirao |
| author_facet | Nobumichi Tanaka Kiyohide Fujimoto Akihide Hirayama Yasushi Nakai Yoshitomo Chihara Satoshi Anai Atsushi Tomioka Keiji Shimada Noboru Konishi Yoshihiko Hirao |
| author_sort | Nobumichi Tanaka |
| collection | DOAJ |
| description | Purpose. The purpose of this study is to investigate whether the clinicopathological biopsy findings can predict the oncological outcome in patients who undergo radical prostatectomy. Materials and Methods. Between January 1997 and March 2006, 255 patients with clinically localized adenocarcinoma of the prostate (clinical T1-3N0M0) who had undergone retropubic radical prostatectomy were enrolled in this study. None of the patients received neoadjuvant or adjuvant therapy. Clinicopathological parameters were assessed to determine a predictive parameter of biochemical recurrence. Results. Of the total 255 patients, 77 showed biochemical recurrence during the follow-up period. The estimated 5-year overall survival, 5-year cause-specific survival, and 5-year biochemical recurrence-free survival rates were 97.7%, 99.5%, and 67.3%, respectively. Multivariate analysis using the Cox proportional hazards model showed that calculated cancer volume was an independent predictor among the preoperative clinicopathological parameters (𝑃<0.05). SVI and PSM were independent predictors among the postoperative parameters (SVI; 𝑃<0.001, PSM; 𝑃=0.049). Among the significant preoperative and postoperative parameters, calculated cancer volume remained an independent predictive parameter in multivariate analysis (𝑃<0.01). Conclusions. Tumor volume, as calculated by preoperative parameters, is an independent predictor of biochemical recurrence in patients who had undergone radical prostatectomy. |
| format | Article |
| id | doaj-art-53514ea57c624f9cae193db658c985b7 |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-53514ea57c624f9cae193db658c985b72025-02-03T07:24:38ZengWileyAdvances in Urology1687-63691687-63772012-01-01201210.1155/2012/204215204215Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in Patients Who Underwent Retropubic Radical ProstatectomyNobumichi Tanaka0Kiyohide Fujimoto1Akihide Hirayama2Yasushi Nakai3Yoshitomo Chihara4Satoshi Anai5Atsushi Tomioka6Keiji Shimada7Noboru Konishi8Yoshihiko Hirao9Department of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanNara Uro-Oncological Research Group, Kashihara, JapanDepartment of Pathology, Nara Medical University, Nara 634-8522, JapanDepartment of Pathology, Nara Medical University, Nara 634-8522, JapanDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanPurpose. The purpose of this study is to investigate whether the clinicopathological biopsy findings can predict the oncological outcome in patients who undergo radical prostatectomy. Materials and Methods. Between January 1997 and March 2006, 255 patients with clinically localized adenocarcinoma of the prostate (clinical T1-3N0M0) who had undergone retropubic radical prostatectomy were enrolled in this study. None of the patients received neoadjuvant or adjuvant therapy. Clinicopathological parameters were assessed to determine a predictive parameter of biochemical recurrence. Results. Of the total 255 patients, 77 showed biochemical recurrence during the follow-up period. The estimated 5-year overall survival, 5-year cause-specific survival, and 5-year biochemical recurrence-free survival rates were 97.7%, 99.5%, and 67.3%, respectively. Multivariate analysis using the Cox proportional hazards model showed that calculated cancer volume was an independent predictor among the preoperative clinicopathological parameters (𝑃<0.05). SVI and PSM were independent predictors among the postoperative parameters (SVI; 𝑃<0.001, PSM; 𝑃=0.049). Among the significant preoperative and postoperative parameters, calculated cancer volume remained an independent predictive parameter in multivariate analysis (𝑃<0.01). Conclusions. Tumor volume, as calculated by preoperative parameters, is an independent predictor of biochemical recurrence in patients who had undergone radical prostatectomy.http://dx.doi.org/10.1155/2012/204215 |
| spellingShingle | Nobumichi Tanaka Kiyohide Fujimoto Akihide Hirayama Yasushi Nakai Yoshitomo Chihara Satoshi Anai Atsushi Tomioka Keiji Shimada Noboru Konishi Yoshihiko Hirao Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in Patients Who Underwent Retropubic Radical Prostatectomy Advances in Urology |
| title | Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in Patients Who Underwent Retropubic Radical Prostatectomy |
| title_full | Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in Patients Who Underwent Retropubic Radical Prostatectomy |
| title_fullStr | Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in Patients Who Underwent Retropubic Radical Prostatectomy |
| title_full_unstemmed | Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in Patients Who Underwent Retropubic Radical Prostatectomy |
| title_short | Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in Patients Who Underwent Retropubic Radical Prostatectomy |
| title_sort | calculated tumor volume is an independent predictor of biochemical recurrence in patients who underwent retropubic radical prostatectomy |
| url | http://dx.doi.org/10.1155/2012/204215 |
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