TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF-κB signaling pathway

TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF-κB signaling pathway

Objective This study was designed to observe the effect of toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway activity on sepsis-associated acute kidney injury (SA-AKI), thereby providing new considerations for the prevention and treatment of SA-AKI.Methods The rats were divided into...

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Bibliographic Details
Main Authors: Yan-mei Xia, Yu-qian Guan, Ji-fang Liang, Wei-dong Wu
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Sepsis-associated acute kidney injury (SA-AKI)
TAK-242
oxidative stress
mitochondrial dysfunction
inflammatory factors
toll-like receptor 4 (TLR4)/nuclear factor κB (NF-κB) signaling pathway
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2313176
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https://www.tandfonline.com/doi/10.1080/0886022X.2024.2313176

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