A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patients
BackgroundAbnormal regulation of food intake in overweight/obese type 2 diabetes mellitus (T2DM) patients is an important cause of energy intake imbalance, and studies have demonstrated that the “gut-brain axis” is involved in a wide range of metabolic regulation through neural and endocrine process...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1612722/full |
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| author | Mingxuan Gao Liya Gong Yanmei Zeng Dongling Li Junyan Wen Ying Guo Zhujia Li Jingwen Luo Chunling Chen Ge Wen |
| author_facet | Mingxuan Gao Liya Gong Yanmei Zeng Dongling Li Junyan Wen Ying Guo Zhujia Li Jingwen Luo Chunling Chen Ge Wen |
| author_sort | Mingxuan Gao |
| collection | DOAJ |
| description | BackgroundAbnormal regulation of food intake in overweight/obese type 2 diabetes mellitus (T2DM) patients is an important cause of energy intake imbalance, and studies have demonstrated that the “gut-brain axis” is involved in a wide range of metabolic regulation through neural and endocrine processes, which has become a key breakthrough in revealing the abnormalities of food intake behaviors in T2DM patients.ObjectiveExploring the mechanism of action of abnormal regulation of ingestive desire in overweight/obese T2DM patients by integrating multimodal MRI techniques with microbiological analysis based on the gut-brain axis.MethodsThirty-one patients with overweight/obese type 2 diabetes mellitus (Group A), 17 patients with simple obesity with abnormal glucose metabolism (Group B), and 14 patients with simple obesity with normal glucose metabolism (Group C) were recruited, and clinical data, MRI, and stool specimens were collected to analyze the correlation between the imaging indicators and the intestinal flora, and clinical data.ResultsCompared with Group C, the abundance of Prevotella and Bifidobacterium in Group A and Group B was significantly reduced, while the abundance of Bacteroides, Fusobacterium, and Phascolarctobacterium was significantly increased. Meanwhile, in Group A and Group B, and Bifidobacterium were negatively correlated with HbA1c, thirst score, and FC values of the left supraoccipital gyrus and bilateral thalamus in the population with abnormal glucose metabolism; Bacteroides were negatively correlated with ALFF values of the right inferior frontal gyrus capitellum, and positively correlated with FC values of the left supraoccipital gyrus and bilateral thalamus, and so on.ConclusionAbnormal desire to ingest is the result of functional changes in brain regions, dysregulation of flora metabolism and neuroimmune interactions, providing a theoretical basis for clinical diagnosis and treatment targeting the gut-brain axis. |
| format | Article |
| id | doaj-art-532f4416f29d4a8c89a0faeec33df95c |
| institution | OA Journals |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-532f4416f29d4a8c89a0faeec33df95c2025-08-20T02:07:38ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-06-011910.3389/fnins.2025.16127221612722A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patientsMingxuan Gao0Liya Gong1Yanmei Zeng2Dongling Li3Junyan Wen4Ying Guo5Zhujia Li6Jingwen Luo7Chunling Chen8Ge Wen9Department of Medical Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Medical Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology, Nanfang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology, Nanfang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Medical Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Medical Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Medical Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Medical Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Medical Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Medical Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, ChinaBackgroundAbnormal regulation of food intake in overweight/obese type 2 diabetes mellitus (T2DM) patients is an important cause of energy intake imbalance, and studies have demonstrated that the “gut-brain axis” is involved in a wide range of metabolic regulation through neural and endocrine processes, which has become a key breakthrough in revealing the abnormalities of food intake behaviors in T2DM patients.ObjectiveExploring the mechanism of action of abnormal regulation of ingestive desire in overweight/obese T2DM patients by integrating multimodal MRI techniques with microbiological analysis based on the gut-brain axis.MethodsThirty-one patients with overweight/obese type 2 diabetes mellitus (Group A), 17 patients with simple obesity with abnormal glucose metabolism (Group B), and 14 patients with simple obesity with normal glucose metabolism (Group C) were recruited, and clinical data, MRI, and stool specimens were collected to analyze the correlation between the imaging indicators and the intestinal flora, and clinical data.ResultsCompared with Group C, the abundance of Prevotella and Bifidobacterium in Group A and Group B was significantly reduced, while the abundance of Bacteroides, Fusobacterium, and Phascolarctobacterium was significantly increased. Meanwhile, in Group A and Group B, and Bifidobacterium were negatively correlated with HbA1c, thirst score, and FC values of the left supraoccipital gyrus and bilateral thalamus in the population with abnormal glucose metabolism; Bacteroides were negatively correlated with ALFF values of the right inferior frontal gyrus capitellum, and positively correlated with FC values of the left supraoccipital gyrus and bilateral thalamus, and so on.ConclusionAbnormal desire to ingest is the result of functional changes in brain regions, dysregulation of flora metabolism and neuroimmune interactions, providing a theoretical basis for clinical diagnosis and treatment targeting the gut-brain axis.https://www.frontiersin.org/articles/10.3389/fnins.2025.1612722/fulltype 2 diabetes mellitusmagnetic resonance imaginggut floraneuroimagingappetite |
| spellingShingle | Mingxuan Gao Liya Gong Yanmei Zeng Dongling Li Junyan Wen Ying Guo Zhujia Li Jingwen Luo Chunling Chen Ge Wen A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patients Frontiers in Neuroscience type 2 diabetes mellitus magnetic resonance imaging gut flora neuroimaging appetite |
| title | A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patients |
| title_full | A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patients |
| title_fullStr | A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patients |
| title_full_unstemmed | A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patients |
| title_short | A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patients |
| title_sort | magnetic resonance imaging and gut flora based study of intake desire in overweight obese type 2 diabetes mellitus patients |
| topic | type 2 diabetes mellitus magnetic resonance imaging gut flora neuroimaging appetite |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1612722/full |
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