Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8

Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8

Abstract After a peripheral nerve injury, Schwann cells (SCs), the myelinating glia of the peripheral nervous system, convert into repair cells that foster axonal regrowth, and then remyelinate or re-ensheath regenerated axons, thereby ensuring functional recovery. The efficiency of this mechanism d...

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Main Authors: Nadège Hertzog, Mert Duman, Maëlle Bochud, Valérie Brügger-Verdon, Maren Gerhards, Felicia Schön, Franka Dorndecker, Dies Meijer, Robert Fledrich, Ruth Stassart, Devanarayanan Siva Sankar, Jörn Dengjel, Sofía Raigón López, Claire Jacob
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-55835-9
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https://doi.org/10.1038/s41467-025-55835-9

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